熊果苷 /Arbutin
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货号：A309050
同义名：
β-Arbutin;NSC 4036
Arbutin is an inhibitor of tyrosinase with IC50 of 1.09 mM and can prevent the formation of melanin. It is a glycosylated hydroquinone found in the leaves of arctostaphylos uvaursi.
Arbutin 化学结构
Arbutin 3D分子结构
规格
价格
会员价
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Arbutin 纯度/质量文件 产品仅供科研
货号：A309050
标准纯度：
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Arbutin 质控信息
Hexylresorcinol
+++
diphenolase, IC50: 0.85 μM
++
monophenolase, IC50: 1.24 μM
+++
diphenolase, IC50: 0.85 μM
monophenolase, IC50: 0.85 μM
99%+
Aloin
✔
98%
Arbutin
+
tyrosinase, IC50: 1.09 mM
98%
Monobenzone
✔
98%
Deoxyarbutin
++++
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Arbutin 生物活性
靶点
tyrosinase
tyrosinase, IC50:1.09 mM
描述
Arbutin is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[3] [4] [5] [6]
Arbutin 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02945891
Cervical Cancer
Not Applicable
Active, not recruiting
December 2018
Norway
... 展开 >> Ostfold Hospital Trust
Fredrikstad, Norway
Oslo University Hospital, Molecular Pathology
Oslo, Norway
Oslo University Hospital, Ullevål
Oslo, Norway
Radiumhospital
Oslo, Norway 收起 <<
NCT00781625
Urinary Tract Infections
Not Applicable
Unknown
December 2010
Norway
... 展开 >> Akershus Universitetssykehus HF
Recruiting
Lørenskog, Akershus, Norway, 1478
Contact: Caroline U Skagemo, MD +47 02900111 cask@ahus.no
Contact: Gunn Iren Meling, PhD, MD +47 02900 111 gmel@ahus.no
Principal Investigator: Caroline U Skagemo, MD
St.Olavs Hospital
Active, not recruiting
Trondheim, Norway, 7006 收起 <<
NCT02130713
Chronic Bacterial Prostatitis
Phase 4
Completed
-
Italy
... 展开 >> policlinico Umberto I - Department of Gynecological-Obstetrics Sciences and Urological Sciences
Roma, Italy, 00161 收起 <<
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Arbutin 参考文献
[1] Tada M, Kohno M, Niwano Y. Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L-tyrosine and L-DOPA. BMC Biochem. 2014 Oct 9;15:23.
[2] Lee HJ, Kim KW. Anti-inflammatory effects of arbutin in lipopolysaccharide-stimulated BV2 microglial cells. Inflamm Res. 2012 Aug;61(8):817-25.
[3] Garcia-Jimenez A, Teruel-Puche JA, Berna J, Rodriguez-Lopez JN, Tudela J, Garcia-Canovas F. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330
[4] Maeda K, Fukuda M. Arbutin: mechanism of its depigmenting action in human melanocyte culture. J Pharmacol Exp Ther. 1996 Feb;276(2):765-9
[5] Jiang L, Wang D, Zhang Y, Li J, Wu Z, Wang Z, Wang D. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054
[6] Wang CQ, Wang XM, Li BL, Zhang YM, Wang L. Arbutin suppresses osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway. FEBS Open Bio. 2021 Jan;11(1):289-299
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Arbutin 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.67mL
0.73mL
0.37mL
18.37mL
3.67mL
1.84mL
36.73mL
7.35mL
3.67mL
Arbutin 技术信息
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