Notoginsenoside Ft1, a natural saponin isolated and purified from the roots of Panax notoginseng, may accelerate diabetic wound healing by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response, which provided a great potential application of it in clinics for patients with diabetic foot ulcers, arrest the proliferation and elicited the apoptosis of SH-SY5Y cells possibly viap38 MAPK and ERK1/2 pathways, which indicates the potential therapeutic effect of it on human neuroblastoma, activate both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries, and enhance platelet aggregation by activating a signalling network mediated through P2Y12 receptors.
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Notoginsenoside Ft1, a natural saponin isolated and purified from the roots of Panax notoginseng, may accelerate diabetic wound healing by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response, which provided a great potential application of it in clinics for patients with diabetic foot ulcers, arrest the proliferation and elicited the apoptosis of SH-SY5Y cells possibly via p38 MAPK and ERK1/2 pathways, which indicates the potential therapeutic effect of it on human neuroblastoma, activate both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries, and enhance platelet aggregation by activating a signalling network mediated through P2Y12 receptors. Notoginsenoside Ft1 is a stimulator of angiogenesis via HIF-1α-mediated VEGF expression, with PI3K/AKT and Raf/MEK/ERK signaling cascades concurrently participating in the process.
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