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Nedisertib {[allProObj[0].p_purity_real_show]}

货号：A778486 同义名： M3814;Peposertib

M-3814, also known as MSC2490484A and nedisertib, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities.

Nedisertib 化学结构 CAS号：1637542-33-6
Nedisertib 化学结构
CAS号：1637542-33-6
Nedisertib 3D分子结构
CAS号：1637542-33-6
Nedisertib 化学结构 CAS号：1637542-33-6
Nedisertib 3D分子结构 CAS号：1637542-33-6
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Nedisertib 纯度/质量文件 产品仅供科研

货号：A778486 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DNA-PK ↓ 其他靶点 纯度
PI-103 ++

DNA-PK, IC50: 23 nM

 		99%+
CC-115 +++

DNA-PK, IC50: 0.013 μM

 		mTOR 98+%
Samotolisib ✔ 99%+
NU 7026 +

DNA-PK, IC50: 0.23 μM

 		PI3K 98+%
PIK-75 HCl ++++

DNA-PK, IC50: 2 nM

 		99%+
PP121 +

DNA-PK, IC50: 60 nM

 		VEGFR,PDGFR 99%+
KU-0060648 ++++

DNA-PK, IC50: 5 nM

 		99%
KU-57788 +++

DNA-PK, IC50: 14 nM

 		99%+
LTURM34 ++

DNA-PK, IC50: 0.034 μM

 		98%+
SF2523 +++

DNA-PK, IC50: 9 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Nedisertib 生物活性

描述 M-3814, also known as MSC2490484A and nedisertib, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK.

Nedisertib 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02316197 Advanced Solid Tumors ... 展开 >> Chronic Lymphocytic Leukemia 收起 << Phase 1 Completed - Germany ... 展开 >> Please contact the Merck KGaA Communication Center Darmstadt, Germany 收起 <<
NCT02516813 Advanced Solid Tumors Phase 1 Recruiting January 8, 2021 United States, California ... 展开 >> Research site Recruiting Fresno, California, United States, 93720 United States, Florida Research site Recruiting Fort Lauderdale, Florida, United States, 33308 Research site Recruiting Miami, Florida, United States, 33136-1002 United States, Montana Research site Recruiting Billings, Montana, United States, 59101 United States, New York Research site Recruiting Bronx, New York, United States, 10461 United States, Pennsylvania Research site Recruiting Philadelphia, Pennsylvania, United States, 19107 United States, Texas Research site Not yet recruiting Houston, Texas, United States, 77030 United States, Washington Research site Completed Tacoma, Washington, United States, 98405 Belgium Research site Active, not recruiting Leuven, Belgium Denmark Research site Recruiting Copenhagen, Denmark, 2100 Research site Recruiting Herlev, Denmark Germany Research site Active, not recruiting Freiburg, Baden Wuerttemberg, Germany, 79106 Research site Recruiting Heidelberg, Baden Wuerttemberg, Germany Research site Recruiting Mannheim, Baden Wuerttemberg, Germany Research site Recruiting Tuebingen, Baden Wuerttemberg, Germany, 72076 Research site Recruiting Mainz, Rhineland-Palatinate, Germany, 55131 Research site Recruiting Dresden, Sachsen, Germany, 1307 Research site Recruiting Kiel, Schleswig-Holstein, Germany, 24105 Research site Recruiting Berlin, Germany, 12200 Netherlands Research site Recruiting Amsterdam, Netherlands, 1066 CX Research site 1 Active, not recruiting Amsterdam, Netherlands Norway Research site Active, not recruiting Oslo, Norway Sweden Research site Recruiting Solna, Sweden, 17176 收起 <<
NCT03724890 Oncology Soli... 展开 >>d Tumors 收起 << Phase 1 Recruiting October 9, 2020 United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute, Inc Recruiting Tampa, Florida, United States, 33612 United States, Tennessee Tennessee Oncology- DDU Recruiting Nashville, Tennessee, United States, 37205 收起 <<

Nedisertib 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.38mL

2.08mL

1.04mL

20.75mL

4.15mL

2.08mL

Nedisertib 技术信息

CAS号1637542-33-6
分子式C24H21ClFN5O3
分子量 481.907
别名 M3814;Peposertib;MSC2490484A
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度
动物实验配方

Tags: Nedisertib | M3814;Peposertib;MSC2490484A | DNA-PK | AmBeed-信号通路专用抑制剂 | Nedisertib 纯度/质量文件 | Nedisertib 亚型比较 | Nedisertib 生物活性 | Nedisertib 临床数据 | Nedisertib 实验方案 | Nedisertib 技术信息

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