产品说明书

	同义名 :	M3814;Peposertib;MSC2490484A
	CAS号 :	1637542-33-6
	货号 :	A778486
	分子式 :	C24H21ClFN5O3
	纯度 :	98%
	分子量 :	481.907
	MDL号 :	MFCD31619234
	存储条件：	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

M-3814, also known as MSC2490484A and nedisertib, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK.

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02316197	Advanced Solid Tumors ... 展开 >> Chronic Lymphocytic Leukemia 收起 <<	Phase 1	Completed	-	Germany ... 展开 >> Please contact the Merck KGaA Communication Center Darmstadt, Germany 收起 <<
NCT02516813	Advanced Solid Tumors	Phase 1	Recruiting	January 8, 2021	United States, California ... 展开 >> Research site Recruiting Fresno, California, United States, 93720 United States, Florida Research site Recruiting Fort Lauderdale, Florida, United States, 33308 Research site Recruiting Miami, Florida, United States, 33136-1002 United States, Montana Research site Recruiting Billings, Montana, United States, 59101 United States, New York Research site Recruiting Bronx, New York, United States, 10461 United States, Pennsylvania Research site Recruiting Philadelphia, Pennsylvania, United States, 19107 United States, Texas Research site Not yet recruiting Houston, Texas, United States, 77030 United States, Washington Research site Completed Tacoma, Washington, United States, 98405 Belgium Research site Active, not recruiting Leuven, Belgium Denmark Research site Recruiting Copenhagen, Denmark, 2100 Research site Recruiting Herlev, Denmark Germany Research site Active, not recruiting Freiburg, Baden Wuerttemberg, Germany, 79106 Research site Recruiting Heidelberg, Baden Wuerttemberg, Germany Research site Recruiting Mannheim, Baden Wuerttemberg, Germany Research site Recruiting Tuebingen, Baden Wuerttemberg, Germany, 72076 Research site Recruiting Mainz, Rhineland-Palatinate, Germany, 55131 Research site Recruiting Dresden, Sachsen, Germany, 1307 Research site Recruiting Kiel, Schleswig-Holstein, Germany, 24105 Research site Recruiting Berlin, Germany, 12200 Netherlands Research site Recruiting Amsterdam, Netherlands, 1066 CX Research site 1 Active, not recruiting Amsterdam, Netherlands Norway Research site Active, not recruiting Oslo, Norway Sweden Research site Recruiting Solna, Sweden, 17176 收起 <<
NCT03724890	Oncology Soli... 展开 >>d Tumors 收起 <<	Phase 1	Recruiting	October 9, 2020	United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute, Inc Recruiting Tampa, Florida, United States, 33612 United States, Tennessee Tennessee Oncology- DDU Recruiting Nashville, Tennessee, United States, 37205 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.08mL 0.42mL 0.21mL	10.38mL 2.08mL 1.04mL	20.75mL 4.15mL 2.08mL