生物活性 | |||
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靶点 |
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描述 | NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM[1]. NU7026 enhances the cytotoxic effects of ionizing radiation (IR) in cells proficient in DNA-PK, evidenced by a potentiation factor at 90% cell kill (PF90) of 1.51±0.04[1]. In vitro, at a 10 μM concentration, which itself is not toxic to cells, NU7026 4-hour exposure combined with 3 Gy of radiation to significantly increase radiosensitivity in CH1 human ovarian cancer cells[3]. |
细胞研究 | |||||
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细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
HeLa cells | Function assay | Inhibition of DNA dependent protein kinase isolated from HeLa cells, IC50=0.23 μM | 15658870 | ||
HeLa cells | Function assay | Inhibition of mTOR protein isolated from HeLa cells, IC50=6.4 μM | 15658870 |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.55mL 0.71mL 0.36mL |
17.77mL 3.55mL 1.78mL |
35.55mL 7.11mL 3.55mL |
参考文献 |
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