NADP sodium, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP sodium is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH). NADP differs from NAD in only the presence of an additional phosphate group esterified to the 2'-hydroxyl group of the ribose at the adenine end and yet NADP is confined with few exceptions to the reactions of reductive biosynthesis, whereas NAD is used almost exclusively in oxidative degradations[1]. NAD(P)-dependent enzymes generally share a common open alpha/beta fold with few exceptions only recently structurally characterized. The NH2-terminal mononucleotide binding domain is less variable than the COOH-terminal half, probably because it involves the binding of the ADP moiety of NAD(P) invariant in all examined systems[2].
搜索
