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NADP sodium salt

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Chemical Structure| 1184-16-3 同义名 : 三磷酸吡定核苷酸;辅酶Ⅱ(NADP 钠盐) ;Sodium NADP
CAS号 : 1184-16-3
货号 : A407582
分子式 : C21H27N7NaO17P3
纯度 : 99%
分子量 : 765.387
MDL号 : MFCD00036973
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(3.92 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(130.65 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 NADP sodium, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP sodium is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH). NADP differs from NAD in only the presence of an additional phosphate group esterified to the 2'-hydroxyl group of the ribose at the adenine end and yet NADP is confined with few exceptions to the reactions of reductive biosynthesis, whereas NAD is used almost exclusively in oxidative degradations[1]. NAD(P)-dependent enzymes generally share a common open alpha/beta fold with few exceptions only recently structurally characterized. The NH2-terminal mononucleotide binding domain is less variable than the COOH-terminal half, probably because it involves the binding of the ADP moiety of NAD(P) invariant in all examined systems[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01686204 Intestinal Barrier Function ... 展开 >> Chronic Inflammation 收起 << Not Applicable Completed - United States, Wisconsin ... 展开 >> Department of Food Science, Babcock Hall Madison, Wisconsin, United States, 53706 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.31mL

0.26mL

0.13mL

6.53mL

1.31mL

0.65mL

13.07mL

2.61mL

1.31mL
参考文献

[1]Carugo O, Argos P. NADP-dependent enzymes. I: Conserved stereochemistry of cofactor binding. Proteins. 1997 May;28(1):10-28

[2]Carugo O, Argos P. NADP-dependent enzymes. II: Evolution of the mono- and dinucleotide binding domains. Proteins. 1997 May;28(1):29-40