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氧化型辅酶 I /NAD+ {[allProObj[0].p_purity_real_show]}

货号：A141009 同义名： 烟酰胺腺嘌呤二核苷酸 / β-DPN;β-NAD

NAD+ 是一种重要的辅酶，在细胞代谢和能量生成中起关键作用。NAD+ 主要用于代谢研究、衰老研究和细胞能量学的研究。

NAD+ 化学结构 CAS号：53-84-9
NAD+ 化学结构
CAS号：53-84-9
NAD+ 3D分子结构
CAS号：53-84-9
NAD+ 化学结构 CAS号：53-84-9
NAD+ 3D分子结构 CAS号：53-84-9
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NAD+ 纯度/质量文件 产品仅供科研

货号：A141009 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
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NAD+ 生物活性

描述 NAD+ (Nicotinamide adenine dinucleotide) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients[3]. Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective[4]. During human aging, decrease of NAD+ levels is associated with potentially reversible dysfunction in the liver, kidney, skeletal and cardiac muscle, endothelial cells, and neurons. And accumulation of senescent cells may itself be a root cause of decreased NAD+, which in turn could promote dysfunction. On the contrary, the lower NAD+ levels may attenuate SASP, decreasing the pathological influence of senescence[5].

NAD+ 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03517995 Bladder Cancer ... 展开 >> Bladder Tumor Urothelial Carcinoma 收起 << Phase 2 Not yet recruiting July 2022 United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute Not yet recruiting Tampa, Florida, United States, 33612 Contact: Kayoko Kennedy    813-745-1947    kayoko.kennedy@moffitt.org    Contact: Nagi Kumar, Ph.D.    813-745-6885    nagi.kumar@moffitt.org    James A. Haley Veteran's Administration Hospital Not yet recruiting Tampa, Florida, United States, 33612 Contact: Cesar Ercole, M.D.    813-910-4088    cesar.ercole1@va.gov    Principal Investigator: Cesar Ercole, M.D. 收起 <<
NCT00098774 Lymphoma Phase 2 Completed - -
NCT02205762 Langerhans Cell Histiocytosis Phase 2 Phase 3 Recruiting July 2023 United States, Arizona ... 展开 >> Phoenix Children's Hospital Recruiting Phoenix, Arizona, United States, 85006 Contact: Michael Henry, MD       mhenry@phoenixchildrens.com    Principal Investigator: Michael Henry, MD          United States, Arkansas Arkansas Children's Hospital Recruiting Little Rock, Arkansas, United States, 72202 Contact: Kimo Stine, MD       stinekimoc@uams.edu    Principal Investigator: Kimo Stine, MD          United States, California Children's Hospital of Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Rima Jubran, MD       rjubran@chla.usc.edu    Principal Investigator: Rima Jubran, MD          Valley Children's Healthcare Not yet recruiting Madera, California, United States, 93636 Contact: David Samuel, MD       DSamuel@valleychildrens.org    Contact: Faisal Razzaqi, MD       FRazzaqi@valleychildrens.org    Principal Investigator: David Samuel, MD          United States, Connecticut Connecticut Children's Medical Center Not yet recruiting Hartford, Connecticut, United States, 06106 Contact: Andrea Orsey, MD       aorsey@connecticutchildrens.org    Principal Investigator: Andrea Orsey, MD          United States, District of Columbia Children's National Medical Center Recruiting Washington, District of Columbia, United States, 20010 Contact: Stephan Ladisch, MD       sladisch@childrensnational.org    Contact: Jay Greenberg, MD       jagreenb@childrensnational.org    United States, Maryland Johns Hopkins University Not yet recruiting Baltimore, Maryland, United States, 21287 Contact: Elias Zambidis, MD       EZambid1@jhmi.edu    Contact: Christine Pratilas, MD       Cpratil1@jhmi.edu    United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Mary Huang, MD    617-726-2737    mshuang@partners.org    Principal Investigator: Mary Huang, MD          Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Barbara Degar, MD    617-632-6801    bdegar@partners.org    Principal Investigator: Barbara Degar, MD          United States, Minnesota Children's Minnesota Recruiting Minneapolis, Minnesota, United States, 55404 Contact: Michael Richards, MD       Michael.richards@childrensmn.org    Contact: Nathan Gossai, MD       nathan.gossai@childrensmn.org    United States, New Jersey Hackensack University Medical Center Recruiting Hackensack, New Jersey, United States, 07601 Contact: Steven Diamond, MD       Steven.Diamond@hackensackmeridian.org    Contact: Burton Appel, MD       Burton.appel@hackensackmeridian.org    United States, New York Cohen Children's Medical Center Recruiting New Hyde Park, New York, United States, 11040 Contact: Carolyn Fein Levy, MD       clevy4@northwell.edu    Contact: Jeffery Lipton, MD       jlipton@northwell.edu    Columbia University / Herbert Irving Cancer Center Recruiting New York, New York, United States, 10032 Contact: Maria Luis Sulis, MD       mls95@cumc.columbia.edu    Contact: Julia Glade Bender, MD       jg589@cumc.columbia.edu    Staten Island University Hospital Recruiting Staten Island, New York, United States, 10305 Contact: Sarah Vaiselbuh, MD    718-226-6435    svaiselbuh@nshs.edu    Principal Investigator: Sarah Vaiselbuh`, MD          SUNY Upstate Medical University Recruiting Syracuse, New York, United States, 13210 Contact: Melanie Comito, MD       comitom@upstate.edu    Contact: Andrea Dvorak, MD       dvoraka@upstate.edu    United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Michael Jordan, MD    513-636-1773    Michael.jordan@cchmc.org    Contact: Ashish Kumar, MD    513-803-1631    ashish.kumar@cchmc.org    United States, South Carolina Medical Universtiy of South Carolina/Hollings Cancer Center Not yet recruiting Charleston, South Carolina, United States, 29425 Contact: Jacqueline Kraveka, DO    843-792-2957    kravekjm@musc.edu    Principal Investigator: Jacqueline Kraveka, DO          United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Patrick Campbell, MD       patrick.campbell@stjude.org    Principal Investigator: Patrick Campbell, MD          United States, Washington Providence Sacred Heart Children's Hospital Recruiting Spokane, Washington, United States, 99204 Contact: Stefanos Intzes, MD       stefanos.intzes@providence.org    Contact: Judy Felgenhauer, MD       judy.felgenhauer@providence.org 收起 <<

NAD+ 参考文献

[1]Brandt U. Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem. 2006;75:69-92.

[2]Kussmaul L, Hirst J. The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7607-12.

[3]Sultani G, Samsudeen AF, Osborne B, Turner N. NAD+ : A key metabolic regulator with great therapeutic potential. J Neuroendocrinol. 2017 Oct;29(10).

[4]Matasic DS, Brenner C, London B. Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H839-H852.

[5]Mendelsohn AR, Larrick JW. Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies. Rejuvenation Res. 2019 Jun;22(3):261-266.

NAD+ 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.51mL

0.30mL

0.15mL

7.54mL

1.51mL

0.75mL

15.07mL

3.01mL

1.51mL

NAD+ 技术信息

CAS号53-84-9
分子式C21H27N7O14P2
分子量 663.425
别名 烟酰胺腺嘌呤二核苷酸 ;β-DPN;β-NAD;BRN3584133;Nadide;Nicotinamide adenine dinucleotide;NAD+ (free acid);β-Nicotinamide Adenine Dinucleotide
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

H2O: 40 mg/mL(60.29 mM)，配合低频超声助溶
动物实验配方

Tags: NAD+ | β-DPN;β-NAD;BRN3584133;Nadide;Nicotinamide adenine dinucleotide;NAD+ (free acid);β-Nicotinamide Adenine Dinucleotide | 烟酰胺腺嘌呤二核苷酸 | Additive and Auxiliary Reagent | Vitamin | AmBeed-信号通路专用抑制剂 | NAD+ 纯度/质量文件 | NAD+ 生物活性 | NAD+ 临床数据 | NAD+ 参考文献 | NAD+ 实验方案 | NAD+ 技术信息

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