产品说明书
NAD+
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同义名 : | 烟酰胺腺嘌呤二核苷酸 ;β-DPN;β-NAD;BRN3584133;Nadide;Nicotinamide adenine dinucleotide;NAD+ (free acid);β-Nicotinamide Adenine Dinucleotide |
| CAS号 : | 53-84-9 | |
| 货号 : | A141009 | |
| 分子式 : | C21H27N7O14P2 | |
| 纯度 : | 98% | |
| 分子量 : | 663.425 | |
| MDL号 : | MFCD00036253 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 40 mg/mL(60.29 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NAD+ (Nicotinamide adenine dinucleotide) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients[3]. Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes, including sirtuins and poly(ADP-ribose) polymerases that regulate posttranslational modifications, DNA damage responses, and Ca2+ signaling. Supplementation of NAD+ precursors, including nicotinamide riboside that boosts or repletes the NAD+ metabolome, may be cardioprotective[4]. During human aging, decrease of NAD+ levels is associated with potentially reversible dysfunction in the liver, kidney, skeletal and cardiac muscle, endothelial cells, and neurons. And accumulation of senescent cells may itself be a root cause of decreased NAD+, which in turn could promote dysfunction. On the contrary, the lower NAD+ levels may attenuate SASP, decreasing the pathological influence of senescence[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03517995 | Bladder Cancer ... 展开 >> Bladder Tumor Urothelial Carcinoma 收起 << | Phase 2 | Not yet recruiting | July 2022 | United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute Not yet recruiting Tampa, Florida, United States, 33612 Contact: Kayoko Kennedy 813-745-1947 kayoko.kennedy@moffitt.org Contact: Nagi Kumar, Ph.D. 813-745-6885 nagi.kumar@moffitt.org James A. Haley Veteran's Administration Hospital Not yet recruiting Tampa, Florida, United States, 33612 Contact: Cesar Ercole, M.D. 813-910-4088 cesar.ercole1@va.gov Principal Investigator: Cesar Ercole, M.D. 收起 << |
| NCT00098774 | Lymphoma | Phase 2 | Completed | - | - |
| NCT02205762 | Langerhans Cell Histiocytosis | Phase 2 Phase 3 | Recruiting | July 2023 | United States, Arizona ... 展开 >> Phoenix Children's Hospital Recruiting Phoenix, Arizona, United States, 85006 Contact: Michael Henry, MD mhenry@phoenixchildrens.com Principal Investigator: Michael Henry, MD United States, Arkansas Arkansas Children's Hospital Recruiting Little Rock, Arkansas, United States, 72202 Contact: Kimo Stine, MD stinekimoc@uams.edu Principal Investigator: Kimo Stine, MD United States, California Children's Hospital of Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Rima Jubran, MD rjubran@chla.usc.edu Principal Investigator: Rima Jubran, MD Valley Children's Healthcare Not yet recruiting Madera, California, United States, 93636 Contact: David Samuel, MD DSamuel@valleychildrens.org Contact: Faisal Razzaqi, MD FRazzaqi@valleychildrens.org Principal Investigator: David Samuel, MD United States, Connecticut Connecticut Children's Medical Center Not yet recruiting Hartford, Connecticut, United States, 06106 Contact: Andrea Orsey, MD aorsey@connecticutchildrens.org Principal Investigator: Andrea Orsey, MD United States, District of Columbia Children's National Medical Center Recruiting Washington, District of Columbia, United States, 20010 Contact: Stephan Ladisch, MD sladisch@childrensnational.org Contact: Jay Greenberg, MD jagreenb@childrensnational.org United States, Maryland Johns Hopkins University Not yet recruiting Baltimore, Maryland, United States, 21287 Contact: Elias Zambidis, MD EZambid1@jhmi.edu Contact: Christine Pratilas, MD Cpratil1@jhmi.edu United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Mary Huang, MD 617-726-2737 mshuang@partners.org Principal Investigator: Mary Huang, MD Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Barbara Degar, MD 617-632-6801 bdegar@partners.org Principal Investigator: Barbara Degar, MD United States, Minnesota Children's Minnesota Recruiting Minneapolis, Minnesota, United States, 55404 Contact: Michael Richards, MD Michael.richards@childrensmn.org Contact: Nathan Gossai, MD nathan.gossai@childrensmn.org United States, New Jersey Hackensack University Medical Center Recruiting Hackensack, New Jersey, United States, 07601 Contact: Steven Diamond, MD Steven.Diamond@hackensackmeridian.org Contact: Burton Appel, MD Burton.appel@hackensackmeridian.org United States, New York Cohen Children's Medical Center Recruiting New Hyde Park, New York, United States, 11040 Contact: Carolyn Fein Levy, MD clevy4@northwell.edu Contact: Jeffery Lipton, MD jlipton@northwell.edu Columbia University / Herbert Irving Cancer Center Recruiting New York, New York, United States, 10032 Contact: Maria Luis Sulis, MD mls95@cumc.columbia.edu Contact: Julia Glade Bender, MD jg589@cumc.columbia.edu Staten Island University Hospital Recruiting Staten Island, New York, United States, 10305 Contact: Sarah Vaiselbuh, MD 718-226-6435 svaiselbuh@nshs.edu Principal Investigator: Sarah Vaiselbuh`, MD SUNY Upstate Medical University Recruiting Syracuse, New York, United States, 13210 Contact: Melanie Comito, MD comitom@upstate.edu Contact: Andrea Dvorak, MD dvoraka@upstate.edu United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Michael Jordan, MD 513-636-1773 Michael.jordan@cchmc.org Contact: Ashish Kumar, MD 513-803-1631 ashish.kumar@cchmc.org United States, South Carolina Medical Universtiy of South Carolina/Hollings Cancer Center Not yet recruiting Charleston, South Carolina, United States, 29425 Contact: Jacqueline Kraveka, DO 843-792-2957 kravekjm@musc.edu Principal Investigator: Jacqueline Kraveka, DO United States, Tennessee St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Patrick Campbell, MD patrick.campbell@stjude.org Principal Investigator: Patrick Campbell, MD United States, Washington Providence Sacred Heart Children's Hospital Recruiting Spokane, Washington, United States, 99204 Contact: Stefanos Intzes, MD stefanos.intzes@providence.org Contact: Judy Felgenhauer, MD judy.felgenhauer@providence.org 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.51mL 0.30mL 0.15mL |
7.54mL 1.51mL 0.75mL |
15.07mL 3.01mL 1.51mL |
| 参考文献 |
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