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Metronidazole

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Chemical Structure| 443-48-1 同义名 : MNZ;NSC 69587;NSC 50364
CAS号 : 443-48-1
货号 : A114755
分子式 : C6H9N3O3
纯度 : 98%
分子量 : 171.15
MDL号 : MFCD00009750
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(204.49 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(87.64 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • DNA synthesis
描述 Metronidazole is an orally active nitroimidazole antibiotic known for its ability to cross the blood-brain barrier. It is primarily used in the research of anaerobic infections due to its efficacy against a range of anaerobic bacteria and protozoa[1].[2].[3].[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02735395 Chronic Periodontitis Phase 4 Active, not recruiting September 2018 Brazil ... 展开 >> Guarulhos University Guarulhos, São Paulo, Brazil, 07023-070 收起 <<
NCT03169946 Periodontal and Endodontic Les... 展开 >>ion 收起 << Not Applicable Active, not recruiting September 2017 -
NCT02736682 Post Operative Infections Phase 4 Completed - Uganda ... 展开 >> Mulago National Refferal Hospital Kampala, Uganda, 00256 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.84mL

1.17mL

0.58mL

29.21mL

5.84mL

2.92mL

58.43mL

11.69mL

5.84mL
参考文献

[1]Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21.

[2]Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390.

[3]Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10.

[4]Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418.