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甲基-β-环糊精 /Methyl-β-cyclodextrin {[allProObj[0].p_purity_real_show]}

货号:A539125 同义名: 甲基倍他环糊精 / Methyl-beta-cyclodextrin;Randomly methylated β-cyclodextrin

Methyl-β-cyclodextrin是一种环状七糖,,易溶于水,形成稳定的水合物。对非极性物质有增溶作用,可以作为疏水性化合物的增溶剂。它还被广泛用作胆固醇消耗试剂,显著减少网格蛋白依赖性内吞作用并阻止细胞迁移体的形成。

Methyl-β-cyclodextrin 化学结构 CAS号:128446-36-6
Methyl-β-cyclodextrin 化学结构
CAS号:128446-36-6
Methyl-β-cyclodextrin 3D分子结构
CAS号:128446-36-6
Methyl-β-cyclodextrin 化学结构 CAS号:128446-36-6
Methyl-β-cyclodextrin 3D分子结构 CAS号:128446-36-6
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Methyl-β-cyclodextrin 纯度/质量文件 产品仅供科研

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Methyl-β-cyclodextrin 生物活性

描述 Methyl-β-cyclodextrin is a cyclic heptasaccharide utilized for delivering hydrophobic agents due to its property of dissolving nonpolar substances. It is also extensively used as a cholesterol-depleting agent[1]. Methyl-β-cyclodextrin possesses multiple biological activities. It significantly reduces clathrin-dependent endocytosis, thus serving as an endocytosis inhibitor[2]. Methyl-β-cyclodextrin inhibits cell migrasome formation[3]. Methyl-β-cyclodextrin is widely used to enhance cell permeability, thereby increasing the uptake of small molecules such as glucose and nanoparticles. In pharmaceutical formulations, Methyl-β-cyclodextrin is utilized to enhance the bioavailability of drugs[4].

Methyl-β-cyclodextrin 参考文献

[1]Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.

[2]Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.

[3]Yuwei Huang, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug;21(8):991-1002.

[4]Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.

Methyl-β-cyclodextrin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.77mL

0.15mL

0.08mL

3.84mL

0.77mL

0.38mL

7.67mL

1.53mL

0.77mL

Methyl-β-cyclodextrin 技术信息

CAS号128446-36-6
分子式N/A
分子量 1303.3
别名 甲基倍他环糊精 ;Methyl-beta-cyclodextrin;Randomly methylated β-cyclodextrin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度
动物实验配方
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