产品说明书

	同义名 :	甲基倍他环糊精 ;Methyl-beta-cyclodextrin;Randomly methylated β-cyclodextrin
	CAS号 :	128446-36-6
	货号 :	A539125
	分子式 :	N/A
	纯度 :	99%
	分子量 :	1303.3
	MDL号 :	MFCD00074980
	存储条件：	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Methyl-β-cyclodextrin is a cyclic heptasaccharide utilized for delivering hydrophobic agents due to its property of dissolving nonpolar substances. It is also extensively used as a cholesterol-depleting agent[1]. Methyl-β-cyclodextrin possesses multiple biological activities. It significantly reduces clathrin-dependent endocytosis, thus serving as an endocytosis inhibitor[2]. Methyl-β-cyclodextrin inhibits cell migrasome formation[3]. Methyl-β-cyclodextrin is widely used to enhance cell permeability, thereby increasing the uptake of small molecules such as glucose and nanoparticles. In pharmaceutical formulations, Methyl-β-cyclodextrin is utilized to enhance the bioavailability of drugs[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	0.77mL 0.15mL 0.08mL	3.84mL 0.77mL 0.38mL	7.67mL 1.53mL 0.77mL

参考文献

[1]Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638. [2]Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974. [3]Yuwei Huang, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug;21(8):991-1002. [4]Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.