Melittin | Melittin游离 | PLA2 Activator | AmBeed-信号通路专用抑制剂

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蜂毒肽 /Melittin {[allProObj[0].p_purity_real_show]}

货号：A407328 同义名： Melittin游离

Melittin can bind calmodulin in a Ca²⁺-dependent manner and inhibit Na⁺-K⁺-ATPase that plays a vital role in Epilepsy treatment.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Melittin 化学结构
CAS号：20449-79-0

Melittin 3D分子结构
CAS号：20449-79-0

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Melittin 纯度/质量文件产品仅供科研

货号：A407328 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

CaMK 亚型比较

产品名称	CaMKII ↓ ↑	CaMKIII ↓ ↑	CaMKKα ↓ ↑	CaMKKβ ↓ ↑	PKD ↓ ↑	纯度
KN-62	+ CaMKII, Ki: 0.9 μM					98%
KN-93	++ CaMKII, Ki: 0.37 μM					98%
NH125		+++ eEF-2 kinase, IC50: 60 nM				99%+
STO-609			++ CaM-KKα, Ki: 0.25 μM	++++ CaM-KKβ, Ki: 47 nM		98%
CID755673					+++ PKD1, IC50: 180 nM PKD2, IC50: 227 nM	99%+
CRT0066101 2HCl					++++ PKD1, IC50: 1 nM PKD2, IC50: 2 nM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Melittin 生物活性

描述

Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not increase activity of the high molecular weight PLA2^[1]. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. The changes induced by melittin in the cisplatin-sensitive cells led mostly to reduced levels of amino acids in the proline/glutamine/arginine pathway, as well as to decreased levels of carnitines, polyamines, adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+)^[2]. Melittin is the major pain-producing substance of bee venom, by which peripheral persistent pain and hyperalgesia (or allodynia), primary nociceptive neuronal sensitization, and CNS synaptic plasticity (or metaplasticity) can be readily induced and the molecular and cellular mechanisms underlying naturally-occurring venomous biotoxins can be experimentally unraveled^[3].

Melittin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02535416	Healthy	Phase 1	Completed	-	Australia, Queensland ... 展开 >> QPharm, Pty Limited, Royal Brisbane Hospital Herston, Queensland, Australia, 4029 收起 <<
NCT02363946	Alpha-1 Antitrypsin Deficiency	Phase 1	Terminated(Company decision to... 展开 >> terminate the trial) 收起 <<	-	Australia, Victoria ... 展开 >> Nucleus Network Ltd Melbourne, Victoria, Australia, 3004 Germany Universitatsklinikum des Saarlandes Homburg, Germany Netherlands Leiden University Medical Center Leiden, Netherlands, 2333ZA United Kingdom Queen Elizabeth Hospital Edgbaston, Birmingham, United Kingdom, B15 2WB 收起 <<
NCT02363946	-		Terminated(Company decision to... 展开 >> terminate the trial) 收起 <<	-	-

Melittin 参考文献

[1]Steiner MR, Bomalaski JS, Clark MA. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30

[2]Alonezi S, Tusiimire J, Wallace J, Dufton MJ, Parkinson JA, Young LC, Clements CJ, Park JK, Jeon JW, Ferro VA, Watson DG. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016 Oct 13;6(4):35

[3]Chen J, Guan SM, Sun W, Fu H. Melittin, the Major Pain-Producing Substance of Bee Venom. Neurosci Bull. 2016 Jun;32(3):265-72. doi: 10.1007/s12264-016-0024-y. Epub 2016 Mar 17

Melittin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

0.35mL

0.07mL

0.04mL

1.76mL

0.35mL

0.18mL

3.51mL

0.70mL

0.35mL

Melittin 技术信息

CAS号	20449-79-0
分子式	C₁₃₁H₂₂₉N₃₉O₃₁
分子量	2846.463

别名	Melittin游离
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

H₂O: 50 mg/mL(17.57 mM)

动物实验配方

蜂毒肽 /Melittin {[allProObj[0].p_purity_real_show]}

Melittin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Melittin 质控信息

Melittin 生物活性

Melittin 临床研究

Melittin 参考文献

Melittin 实验方案

Melittin 技术信息

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蜂毒肽 /Melittin {[allProObj[0].p_purity_real_show]}

Melittin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Melittin 质控信息

Melittin 生物活性

Melittin 临床研究

Melittin 参考文献

Melittin 实验方案

Melittin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Melittin 纯度/质量文件产品仅供科研