Leptin (22-56) is a biological active fragment of leptin which is a hormone predominantly made by adipose cells and enterocytes that helps to regulate energy balance by inhibiting hunger,
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产品名称 | AMPA receptor ↓ ↑ | GluR ↓ ↑ | mGluR5 ↓ ↑ | NMDA receptor ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
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Evans Blue | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IEM-1754 |
+
GluR3, IC50: 6 μM GluR1, IC50: 6 μM |
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Latrepirdine 2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
(-)-Huperzine A |
+++
AChE (G4 form), Ki: 7 nM |
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CTEP |
++++
mGlu5, IC50: 2.2 nM |
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MPEP |
++
mGluR5, IC50: 36 nM |
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Riluzole | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Leptin is an adipocyte hormone important in appetite, energy homeostasis, neuroendocrine and haematopoietic function [1]. Leptin or leptin fragment administration results in a potent inhibition of ACTH and glucocorticoid secretion. Ob-Ra and Ob-Rb subtypes of leptin receptors are expressed in rat adrenocortical cells, and they interact differently in vivo and in vitro with native leptin and leptin fragments. Leptin (22-56), human is a fragment of native leptin which can interact with isoform of Ob-R. Leptin (22-56), human inhibited corticosterone production from rat adrenocortical-cell cultures suggesting that this region of the leptin molecule may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adreno¬cortical cells [2]. Baseline leptin (22-56) levels were higher in haemodialysis (HD) patients vs. controls(7.14 +/- 7.04 ng/ml vs. 1.86 +/- 1.84, P < 0.02). Leptin(22-56) had a significant negative correlation with the erythropoietin to haematocrit ratio (T = -0.42, P < 0.01) suggesting Leptin(22-56) may favour haematopoiesis [1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.25mL 0.05mL 0.03mL |
1.27mL 0.25mL 0.13mL |
2.53mL 0.51mL 0.25mL |
CAS号 | 183598-56-3 |
分子式 | C171H298N50O56 |
分子量 | 3950.5 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(26.58 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |