瘦素(22-56) /Leptin (22-56), human {[allProObj[0].p_purity_real_show]}
货号：A251480
Leptin (22-56) is a biological active fragment of leptin which is a hormone predominantly made by adipose cells and enterocytes that helps to regulate energy balance by inhibiting hunger,
Leptin is an adipocyte hormone important in appetite, energy homeostasis, neuroendocrine and haematopoietic function [1]. Leptin or leptin fragment administration results in a potent inhibition of ACTH and glucocorticoid secretion. Ob-Ra and Ob-Rb subtypes of leptin receptors are expressed in rat adrenocortical cells, and they interact differently in vivo and in vitro with native leptin and leptin fragments. Leptin (22-56), human is a fragment of native leptin which can interact with isoform of Ob-R. Leptin (22-56), human inhibited corticosterone production from rat adrenocortical-cell cultures suggesting that this region of the leptin molecule may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adreno¬cortical cells [2]. Baseline leptin (22-56) levels were higher in haemodialysis (HD) patients vs. controls(7.14 +/- 7.04 ng/ml vs. 1.86 +/- 1.84, P < 0.02). Leptin(22-56) had a significant negative correlation with the erythropoietin to haematocrit ratio (T = -0.42, P < 0.01) suggesting Leptin(22-56) may favour haematopoiesis [1].
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