产品说明书
Leptin (22-56), human
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同义名 : | - |
| CAS号 : | 183598-56-3 | |
| 货号 : | A251480 | |
| 分子式 : | C171H298N50O56 | |
| 纯度 : | 98% | |
| 分子量 : | 3950.5 | |
| MDL号 : | MFCD00802382 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(26.58 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Leptin is an adipocyte hormone important in appetite, energy homeostasis, neuroendocrine and haematopoietic function [1]. Leptin or leptin fragment administration results in a potent inhibition of ACTH and glucocorticoid secretion. Ob-Ra and Ob-Rb subtypes of leptin receptors are expressed in rat adrenocortical cells, and they interact differently in vivo and in vitro with native leptin and leptin fragments. Leptin (22-56), human is a fragment of native leptin which can interact with isoform of Ob-R. Leptin (22-56), human inhibited corticosterone production from rat adrenocortical-cell cultures suggesting that this region of the leptin molecule may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adreno¬cortical cells [2]. Baseline leptin (22-56) levels were higher in haemodialysis (HD) patients vs. controls(7.14 +/- 7.04 ng/ml vs. 1.86 +/- 1.84, P < 0.02). Leptin(22-56) had a significant negative correlation with the erythropoietin to haematocrit ratio (T = -0.42, P < 0.01) suggesting Leptin(22-56) may favour haematopoiesis [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.25mL 0.05mL 0.03mL |
1.27mL 0.25mL 0.13mL |
2.53mL 0.51mL 0.25mL |
| 参考文献 |
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