货号:A303353 同义名: 贝壳杉烯酸 / kaurenoate;kaur-16-en-18-oic acid
Kaurenoic acid是一种天然二萜化合物,具有抗炎特性,通过抑制 iNOS 和 COX-2 的表达来发挥作用,可用于抑制炎症疼痛。它还可能通过激活 NO-cyclic GMP-PKG-ATP 敏感型钾通道信号通路抑制炎症。
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描述 | Kaurenoic acid (KA) is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway[3]. Kaurenoic acid dose-dependently inhibited NO production, PGE2 release, COX-2 and iNOS expression at micromolar concentrations in LPS-induced RAW264.7 macrophages with IC50 values of 51.73 (±2.42) μM and 106.09 (±0.27) μM in NO production and PGE(2) release, respectively[4]. KA induced the phosphorylation of Smad2 and Smad3, key activator molecules in TGF-β signaling. Similarly, i.t. KA induced the phosphorylation of Smad2 and increased the expression of α-SMA in mouse lungs[5]. KA increased, in a dose-dependent manner, the survival rate after acetaminophen overdose. KA reduced acetaminophen-induced hepatic necrosis and ALT and AST levels. KA decreased acetaminophen-induced neutrophil and macrophage recruitment, oxidative stress and the production of IL-33, TNF-α and IL-1β, alongside with normalisation of IL-10 levels in the liver[6]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.53mL 3.31mL 1.65mL |
33.06mL 6.61mL 3.31mL |
CAS号 | 6730-83-2 |
分子式 | C20H30O2 |
分子量 | 302.451 |
别名 | 贝壳杉烯酸 ;kaurenoate;kaur-16-en-18-oic acid;Kauren-19-oic acid;CCRIS 1514 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,Store in freezer, under -20°C |
溶解方案 |
DMSO: 105 mg/mL(347.16 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |