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异贝壳杉烯酸 /Kaurenoic acid {[allProObj[0].p_purity_real_show]}

货号:A303353 同义名: 贝壳杉烯酸 / kaurenoate;kaur-16-en-18-oic acid

Kaurenoic acid是一种天然二萜化合物,具有抗炎特性,通过抑制 iNOS 和 COX-2 的表达来发挥作用,可用于抑制炎症疼痛。它还可能通过激活 NO-cyclic GMP-PKG-ATP 敏感型钾通道信号通路抑制炎症。

Kaurenoic acid 化学结构 CAS号:6730-83-2
Kaurenoic acid 化学结构
CAS号:6730-83-2
Kaurenoic acid 3D分子结构
CAS号:6730-83-2
Kaurenoic acid 化学结构 CAS号:6730-83-2
Kaurenoic acid 3D分子结构 CAS号:6730-83-2
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Kaurenoic acid 纯度/质量文件 产品仅供科研

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Kaurenoic acid 生物活性

描述 Kaurenoic acid (KA) is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway[3]. Kaurenoic acid dose-dependently inhibited NO production, PGE2 release, COX-2 and iNOS expression at micromolar concentrations in LPS-induced RAW264.7 macrophages with IC50 values of 51.73 (±2.42) μM and 106.09 (±0.27) μM in NO production and PGE(2) release, respectively[4]. KA induced the phosphorylation of Smad2 and Smad3, key activator molecules in TGF-β signaling. Similarly, i.t. KA induced the phosphorylation of Smad2 and increased the expression of α-SMA in mouse lungs[5]. KA increased, in a dose-dependent manner, the survival rate after acetaminophen overdose. KA reduced acetaminophen-induced hepatic necrosis and ALT and AST levels. KA decreased acetaminophen-induced neutrophil and macrophage recruitment, oxidative stress and the production of IL-33, TNF-α and IL-1β, alongside with normalisation of IL-10 levels in the liver[6].

Kaurenoic acid 参考文献

[1]Fernandes VC, Pereira SI, et al. The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction. Genet Mol Res. 2013 Apr 2;12(2):1005-11.

[2]Choi RJ, Shin EM, et al. Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages. Phytomedicine. 2011 Jun 15;18(8-9):677-82.

[3]Mizokami SS, Arakawa NS, Ambrosio SR, Zarpelon AC, Casagrande R, Cunha TM, Ferreira SH, Cunha FQ, Verri WA Jr. Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. J Nat Prod. 2012 May 25;75(5):896-904

[4]Choi RJ, Shin EM, Jung HA, Choi JS, Kim YS. Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages. Phytomedicine. 2011 Jun 15;18(8-9):677-82

[5]Kim KH, Han JW, Jung SK, Park BJ, Han CW, Joo M. Kaurenoic acid activates TGF-β signaling. Phytomedicine. 2017 Aug 15;32:8-14

[6]Marcondes-Alves L, Fattori V, Borghi SM, Lourenco-Gonzalez Y, Bussmann AJC, Hirooka EY, Casagrande R, Verri WA Jr, Arakawa NS. Kaurenoic acid extracted from Sphagneticola trilobata reduces acetaminophen-induced hepatotoxicity through inhibition of oxidative stress and pro-inflammatory cytokine production in mice. Nat Prod Res. 2019 Mar;33(6):921-924

Kaurenoic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.53mL

3.31mL

1.65mL

33.06mL

6.61mL

3.31mL

Kaurenoic acid 技术信息

CAS号6730-83-2
分子式C20H30O2
分子量 302.451
别名 贝壳杉烯酸 ;kaurenoate;kaur-16-en-18-oic acid;Kauren-19-oic acid;CCRIS 1514
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

DMSO: 105 mg/mL(347.16 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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