Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. Kainic acid is a potent neurotoxin, and induces selective neuronal loss in the rat hippocampus. Kainic acid acts on the kainate receptors, and kainic acid neurotoxicity may be in part mediated by oxidative stress[3]. The neurotoxic properties of kainic acid and ibotenic acid following intrahippocampal injection in neonatal rats and found significant pyramidal cell death following injection of 1.0 microgram kainic acid in 6, 7 and 9-day-old pups. At doses 2.5 or five times this amount, significant pyramidal cell loss was obtained in 5-day-old rats as well[4]. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons[5]. The kainic acid-induced lesions potentiated the locomotor response to both the dopaminergic agonist, d-amphetamine, and the cholinergic antagonist, scopolamine, attenuated the cataleptic response to the dopaminergic antagonist, haloperidol, and potentiated the cataleptic acid and convulsive responses to the cholinergic agonist, pilocarpine[6].
France
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Marseille, France, 13354
Contact: Aïleen Mc Gonigal, MD aileen.mcgonigal@ap-hm.fr
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France
... 展开 >> Assistance Publique Hôpitaux de Marseille
Recruiting
Marseille, France, 13354
Contact: Aïleen Mc Gonigal, MD aileen.mcgonigal@ap-hm.fr
Chu Tours
Not yet recruiting
Tours, France
Contact: Bertrand DE TOFFOL, MD/PhD bertrand.detoffol@univ-tours.fr 收起 <<
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