Kainic acid
产品说明书
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同义名 : | - |
| CAS号 : | 487-79-6 | |
| 货号 : | A537335 | |
| 分子式 : | C10H15NO4 | |
| 纯度 : | 98% | |
| 分子量 : | 213.23 | |
| MDL号 : | MFCD00077806 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(234.49 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(117.24 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. Kainic acid is a potent neurotoxin, and induces selective neuronal loss in the rat hippocampus. Kainic acid acts on the kainate receptors, and kainic acid neurotoxicity may be in part mediated by oxidative stress[3]. The neurotoxic properties of kainic acid and ibotenic acid following intrahippocampal injection in neonatal rats and found significant pyramidal cell death following injection of 1.0 microgram kainic acid in 6, 7 and 9-day-old pups. At doses 2.5 or five times this amount, significant pyramidal cell loss was obtained in 5-day-old rats as well[4]. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons[5]. The kainic acid-induced lesions potentiated the locomotor response to both the dopaminergic agonist, d-amphetamine, and the cholinergic antagonist, scopolamine, attenuated the cataleptic response to the dopaminergic antagonist, haloperidol, and potentiated the cataleptic acid and convulsive responses to the cholinergic agonist, pilocarpine[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02108015 | Healthy Volunteers | Phase 1 | Terminated | - | United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 << |
| NCT03244345 | Depression and Epilepsy | Not Applicable | Recruiting | February 20, 2021 | France ... 展开 >> Assistance Publique Hôpitaux de Marseille Recruiting Marseille, France, 13354 Contact: Aïleen Mc Gonigal, MD aileen.mcgonigal@ap-hm.fr Chu Tours Not yet recruiting Tours, France Contact: Bertrand DE TOFFOL, MD/PhD bertrand.detoffol@univ-tours.fr 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.69mL 0.94mL 0.47mL |
23.45mL 4.69mL 2.34mL |
46.90mL 9.38mL 4.69mL |
| 参考文献 |
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