Isorhapotogenin is a natural product isolated and purified from the herbs of Gnetum montanum Markgr. Isorhapontigenin (Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Isor effectively relieved Dox-induced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor (30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice[3]. ISO effectively ameliorated lipopolysaccharide-induced ALI by reducing inflammation and oxidative stress, primarily through activation of Nrf2 (Nuclear factor erythroid-2 related factor 2) signaling[4]. ISO protected against oxidative damage induced by brain I/R (cerebral ischemia/reperfusion), and its neuroprotective mechanism may be related to the PKCε/Nrf2/HO-1 pathway[5]. ISO successfully induced breast cancer cell death and cell growth arrest, suggesting this phytochemical is a better alternative for breast cancer treatment[6].
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