产品说明书

Isorhapontigenin

Print
Chemical Structure| 32507-66-7 同义名 : ISOR
CAS号 : 32507-66-7
货号 : A531729
分子式 : C15H14O4
纯度 : 95%
分子量 : 258.269
MDL号 : MFCD12407151
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(193.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isorhapotogenin is a natural product isolated and purified from the herbs of Gnetum montanum Markgr. Isorhapontigenin (Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Isor effectively relieved Dox-induced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor (30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice[3]. ISO effectively ameliorated lipopolysaccharide-induced ALI by reducing inflammation and oxidative stress, primarily through activation of Nrf2 (Nuclear factor erythroid-2 related factor 2) signaling[4]. ISO protected against oxidative damage induced by brain I/R (cerebral ischemia/reperfusion), and its neuroprotective mechanism may be related to the PKCε/Nrf2/HO-1 pathway[5]. ISO successfully induced breast cancer cell death and cell growth arrest, suggesting this phytochemical is a better alternative for breast cancer treatment[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.87mL

0.77mL

0.39mL

19.36mL

3.87mL

1.94mL

38.72mL

7.74mL

3.87mL
参考文献

[1]Zhu C, Zhu Q, et al. Isorhapontigenin induced cell growth inhibition and apoptosis by targeting EGFR-related pathways in prostate cancer. J Cell Physiol. 2017 Apr 19.

[2]Lu Y, Wang A, et al. A Theoretical Study on the Antioxidant Activity of Piceatannol and Isorhapontigenin Scavenging Nitric Oxide and Nitrogen Dioxide Radicals. PLoS One. 2017 Jan 9;12(1):e0169773.

[3]Wang P, Wang M, Hu Y, Chen J, Cao Y, Liu C, Wu Z, Shen J, Lu J, Liu P. Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression. Acta Pharm Sin B. 2021 Mar;11(3):680-693

[4]Yao P, Zhang Z, Cao J. Isorhapontigenin alleviates lipopolysaccharide-induced acute lung injury via modulating Nrf2 signaling. Respir Physiol Neurobiol. 2021 Jul;289:103667

[5]Xue Z, Zhao K, Sun Z, Wu C, Yu B, Kong D, Xu B. Isorhapontigenin ameliorates cerebral ischemia/reperfusion injury via modulating Kinase Cε/Nrf2/HO-1 signaling pathway. Brain Behav. 2021 Jul;11(7):e02143

[6]Subedi L, Teli MK, Lee JH, Gaire BP, Kim MH, Kim SY. A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization. Cancers (Basel). 2019 Dec 5;11(12):1947