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Isoalantolactone
异土木香内酯 /Isoalantolactone
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货号：A249503
同义名：
(+)-Isoalantolactone;Isohelenin
Isoalantolactone is a naturally occuring sesquiterpene lactone isolated from Inula helenium with a role as an apoptosis inducer, an antifungal agent and a plant metabolite.
Isoalantolactone 化学结构
Isoalantolactone 3D分子结构
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Isoalantolactone 纯度/质量文件 产品仅供科研
货号：A249503
标准纯度：
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Isoalantolactone 质控信息
Isoalantolactone 生物活性
描述
Isoalantolactone, a sesquiterpene lactone compound that can be purified from the roots of Inula helenium L, with antifungal, anti-bacterial, anti-helminthic and anti-proliferative properties. In vitro , Isoalantolactone enhanced the radiosensitivity of UMSCC-10A cells; the sensitivity enhanced ratios (SERs) were 1.44 and 1.63, respectively, for 2.5 and 5 μM[5] 50 values were about 40 μM after 24 h treatment[4]
Isoalantolactone 参考文献
[1] Cai H, Meng X, et al. Growth inhibition effects of isoalantolactone on K562/A02 cells: caspase-dependent apoptotic pathways, S phase arrest, and downregulation of Bcr/Abl. Phytother Res. 2014 Nov;28(11):1679-86.
[2] Rasul A, Khan M, et al. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res. 2013 Oct;36(10):1262-9.
[3] Fan Y, Weng Z, Gao H, et al. Isoalantolactone Enhances the Radiosensitivity of UMSCC-10A Cells via Specific Inhibition of Erk1/2 Phosphorylation. PLoS One. 2015;10(12):e0145790. Published 2015 Dec 30.
[4] Jin C, Zhang G, Zhang Y, Hua P, Song G, Sun M, Li X, Tong T, Li B, Zhang X. Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. PLoS One. 2017 Aug 4;12(8):e0181731. doi: 10.1371/journal.pone.0181731. PMID: 28777796; PMCID: PMC5544200.
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Isoalantolactone 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
4.30mL
0.86mL
0.43mL
21.52mL
4.30mL
2.15mL
43.04mL
8.61mL
4.30mL
Isoalantolactone 技术信息
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