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Isoalantolactone

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Chemical Structure| 470-17-7 同义名 : (+)-Isoalantolactone;Isohelenin;NSC 601353;NSC 241036
CAS号 : 470-17-7
货号 : A249503
分子式 : C15H20O2
纯度 : 99%+
分子量 : 232.318
MDL号 : MFCD08689940
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(451.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isoalantolactone, a sesquiterpene lactone compound that can be purified from the roots of Inula helenium L, with antifungal, anti-bacterial, anti-helminthic and anti-proliferative properties. In vitro, Isoalantolactone enhanced the radiosensitivity of UMSCC-10A cells; the sensitivity enhanced ratios (SERs) were 1.44 and 1.63, respectively, for 2.5 and 5 μM[5]. Treating SK-MES-1 cells with 0, 20, and 40 M of Isoalantolactone for 24 h change its morphology: rounded and shrunken cells, and decreased number of cells, the IC50 values were about 40 μM after 24 h treatment[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.30mL

0.86mL

0.43mL

21.52mL

4.30mL

2.15mL

43.04mL

8.61mL

4.30mL
参考文献

[1]Cai H, Meng X, et al. Growth inhibition effects of isoalantolactone on K562/A02 cells: caspase-dependent apoptotic pathways, S phase arrest, and downregulation of Bcr/Abl. Phytother Res. 2014 Nov;28(11):1679-86.

[2]Rasul A, Khan M, et al. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res. 2013 Oct;36(10):1262-9.

[3]Fan Y, Weng Z, Gao H, et al. Isoalantolactone Enhances the Radiosensitivity of UMSCC-10A Cells via Specific Inhibition of Erk1/2 Phosphorylation. PLoS One. 2015;10(12):e0145790. Published 2015 Dec 30.

[4]Jin C, Zhang G, Zhang Y, Hua P, Song G, Sun M, Li X, Tong T, Li B, Zhang X. Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. PLoS One. 2017 Aug 4;12(8):e0181731. doi: 10.1371/journal.pone.0181731. PMID: 28777796; PMCID: PMC5544200.