IWR-1 | IWR-1-endo | Tankyrase Inhibitor | AmBeed-信号通路专用抑制剂

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IWR-1 {[allProObj[0].p_purity_real_show]}

货号：A205590 同义名： IWR-1-endo;endo-IWR 1

IWR-1是一种抑制Wnt/β-连环蛋白信号通路的tankyrase抑制剂。

IWR-1 化学结构
CAS号：1127442-82-3

IWR-1 3D分子结构
CAS号：1127442-82-3

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IWR-1 纯度/质量文件产品仅供科研

货号：A205590 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

IWR-1 生物活性

描述	Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.

IWR-1 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
Escherichia coli BL21 (DE3) cells		Function assay	90 mins	Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins by Western blot analysis, EC50=0.2 μM	22233320
HEK293 cells		Function assay		Displacement of IWR-PB from Axin2 in HEK293 cells by Western blot method	19125156
human DLD1 cells		Function assay	2 h	Induction of Axin2 stabilization in human DLD1 cells assessed as decreased transcription of Axin2 after 2 hrs by RT-PCR method.	19125156
human HEK293T cells		Function assay		Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay, IC50=0.026 μM	22191557

IWR-1 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.42mL

4.88mL

2.44mL

IWR-1 技术信息

CAS号	1127442-82-3
分子式	C₂₅H₁₉N₃O₃
分子量	409.437

别名	IWR-1-endo;endo-IWR 1
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 50 mg/mL(122.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 3% DMSO+2% Tween80+40% PEG300+water 1 mg/mL clear

PO 0.5% CMC-Na 45 mg/mL suspension

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

*在制备母液时，请始终参考产品标签或 MSDS / COA（在产品页面可下载）上所显示的对应批次产品的分子量。

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

Escherichia coli BL21 (DE3) cells		Function assay	90 mins	Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins by Western blot analysis, EC50=0.2 μM	22233320
HEK293 cells		Function assay		Displacement of IWR-PB from Axin2 in HEK293 cells by Western blot method	19125156
human DLD1 cells		Function assay	2 h	Induction of Axin2 stabilization in human DLD1 cells assessed as decreased transcription of Axin2 after 2 hrs by RT-PCR method.	19125156
human HEK293T cells		Function assay		Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay, IC50=0.026 μM	22191557
human HT29 cells		Function assay	24 h	Inhibition of Wnt signaling in human HT29 cells assessed as inhibition of beta-catenin-mediated Tcf/Lef transcriptional activity after 24 hrs by dual luciferase reporter gene assay relative to control, IC50=24.4 μM	24950489
human HT29 cells	25 μM	Function assay	24 h	Inhibition of Wnt signaling in human HT29 cells assessed as inhibition of beta-catenin-mediated Tcf/Lef transcriptional activity at 25 uM after 24 hrs by dual luciferase reporter gene assay relative to control in presence of GSK-3beta inhibitor LiCl	24950489
human SW480 cells		Function assay	40 to 48 h	Inhibition of tankyrase in human SW480 cells assessed as degradation of beta catenin after 40 to 48 hrs, IC50=0.25 μM	23701517
human SW480 cells		Function assay	24 h	Inhibition of tankyrase in human SW480 cells assessed as accumulation of axin2 after 24 hrs by Hoechst dye-based method	23701517
mouse L-Wnt-STF cells		Function assay		Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assay, IC50=0.056 μM	24527792
mouse L-Wnt-STF cells		Function assay		Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assay, IC50=0.131 μM	24527792

IWR-1 {[allProObj[0].p_purity_real_show]}

IWR-1 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

IWR-1 质控信息

IWR-1 生物活性

IWR-1 细胞研究

IWR-1 实验方案

IWR-1 技术信息

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摩尔计算器

靶点

总药量计算器

工作液计算器

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IWR-1 {[allProObj[0].p_purity_real_show]}

IWR-1 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

IWR-1 质控信息

IWR-1 生物活性

IWR-1 细胞研究

IWR-1 实验方案

IWR-1 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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IWR-1 纯度/质量文件产品仅供科研