2-(3,4-Dihydroxyphenyl) ethanol (DPE) is a potent and specific inhibitor of lipoxygenase activities. DPE inhibited platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions. It also inhibited 12-LO activity in intact platelets (IC50, 50 microM) and reduced leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). It's a natural product isolated and purified from the herbs of Canarium album with antioxidant property. The inhibition by DPE of both lipoxygenase activities was stronger than that by oleuropein, caffeic acid, or 7 other related phenolic compounds, especially in intact cells[3]. 2-(3,4-Dihydroxyphenyl) ethanol has antioxidant, antiproliferative, pro-apoptotic, and anti-inflammatory activities, which have the potential to specifically counteract all cancer hallmarks, thus representing the expectant biological activities underlying the anti-tumor properties of this polyphenol[4]. Examination of their suppression effects on nitric oxide production stimulated by lipopolysaccharides in RAW264.7 cells showed that hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol] butyrate exhibited the highest inhibition (IC50 7.0 μM) among the tested compounds[5].
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