Hydroxytyrosol

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Chemical Structure| 10597-60-1 同义名 : 羟基酪醇 ;DOPET;3,4-Dihydroxyphenethyl alcohol;3Hydroxytyrosol3 4dihydroxyphenylethanol (DOPET)Dihydroxyphenylethanol 2(34Dihydroxyphenyl)ethanol (DHPE)34dihydroxyphenolethanol (34DHPEA);Ba2774;3,4-Dihydroxyphenyl ethanol;3-Hydroxytyrosol
CAS号 : 10597-60-1
货号 : A172108
分子式 : C8H10O3
纯度 : 98%
分子量 : 154.163
MDL号 : MFCD01320529
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(778.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(648.66 mM)，配合低频超声助溶

无水乙醇: 45 mg/mL(291.9 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 2-(3,4-Dihydroxyphenyl) ethanol (DPE) is a potent and specific inhibitor of lipoxygenase activities. DPE inhibited platelet 12-LO activity (IC50, 4.2 microM) and PMNL 5-LO activity (IC50, 13 microM) but not cyclooxygenase activity in cell-free conditions. It also inhibited 12-LO activity in intact platelets (IC50, 50 microM) and reduced leukotriene B4 production in intact PMNL stimulated by A23187 (IC50, 26 microM). It's a natural product isolated and purified from the herbs of Canarium album with antioxidant property. The inhibition by DPE of both lipoxygenase activities was stronger than that by oleuropein, caffeic acid, or 7 other related phenolic compounds, especially in intact cells[3]. 2-(3,4-Dihydroxyphenyl) ethanol has antioxidant, antiproliferative, pro-apoptotic, and anti-inflammatory activities, which have the potential to specifically counteract all cancer hallmarks, thus representing the expectant biological activities underlying the anti-tumor properties of this polyphenol[4]. Examination of their suppression effects on nitric oxide production stimulated by lipopolysaccharides in RAW264.7 cells showed that hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol] butyrate exhibited the highest inhibition (IC50 7.0 μM) among the tested compounds[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.49mL

1.30mL

0.65mL

32.43mL

6.49mL

3.24mL

64.87mL

12.97mL

6.49mL
参考文献

[1]Merra E, Calzaretti G, et al. Antioxidant role of hydroxytyrosol on oxidative stress in cadmium-intoxicated rats: different effect in spleen and testes. Drug Chem Toxicol. 2014 Oct;37(4):420-6.

[2]Kohyama N, Nagata T, et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50.

[3]Kohyama N, Nagata T, Fujimoto S, Sekiya K. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci Biotechnol Biochem. 1997 Feb;61(2):347-50

[4]Bernini R, Merendino N, Romani A, Velotti F. Naturally occurring hydroxytyrosol: synthesis and anticancer potential. Curr Med Chem. 2013;20(5):655-70

[5]Sakakura A, Pauze M, Namiki A, Funakoshi -Tago M, Tamura H, Hanaya K, Higashibayashi S, Sugai T. Chemoenzymatic synthesis of hydroxytyrosol monoesters and their suppression effect on nitric oxide production stimulated by lipopolysaccharides. Biosci Biotechnol Biochem. 2019 Feb;83(2):185-191