1-Naphthyl 3,5-dinitrobenzoate是一种有效的 5-脂氧合酶 (5-LOX) 抑制剂，IC₅₀ 分别为 1.04 µM 和 3.6 µM，对 mPGES-1 也有显著抑制作用。该化合物在人全血测定中具有很强的抑制活性 (IC₅₀ = 8.6 μM)，适用于炎症和氧化应激相关疾病的研究。

3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种 5-脂氧合酶 (5-LO) 抑制剂。

4-MMPB是一种选择性的 15-脂氧合酶 (15-LO) 抑制剂。它有效抑制脂氧合酶在脂质代谢中的作用，对前列腺癌的研究具有潜力。

CAY10698是一种高效且选择性的 12-Lipoxygenase (12-LOX) 抑制剂，IC50 为 5.1 μM，对其他 LOX 和 COX 无活性。

5-LOX-IN-1是一种 5-脂氧合酶 (5-LOX) 的抑制剂，IC₅₀ 为 2.3 μM，广泛应用于癌症研究，尤其是在研究与炎症和氧化应激相关的肿瘤中具有潜力。

ThioLox是一种有效的 15-脂氧合酶-1 (15-LOX-1) 抑制剂，Ki 为 3.30 μM，显示出显著的抗炎和神经保护特性，适用于相关疾病的研究。

Phenethyl ferulate 是 Qianghuo 的一种主要成分，对环加氧酶 (COX) 和 5-脂氧合酶 (5-LOX) 具有抑制活性，IC50 分别为 4.35 μM 和 5.75 μM。

Marmesin是一种天然香豆素，具有 COX-2 和 5-LOX 双重抑制作用。它在抗炎和癌症治疗中展现出良好的潜力。

DKI5是一种 LOX-1 抑制剂，IC₅₀ 为 22.5 μM，具有潜在的抗动脉粥样硬化和抗炎症作用。

ML351 is a novel chemotype and the first reported selective inhibitor of 15-LOX-1 with IC50 value of 200 nM.

ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM).

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50s of 0.09, 0.013 and 0.5 μM respectively.

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor with Ki of 197 nM.

Wnt pathway inhibitor 4是一种具有抗癌细胞增殖活性的抗癌剂。

Malotilate is hepatotrophic drug which can selectively inhibit the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways were stimulated, with antifibrotic and hepatoprotective properties.

Zileuton is a reversible 5-lipoxygenase inhibitor with IC50 value of 0.5 µM in rat basophilic leukemia-1 (RBL-1) cells. It also potently inhibited leukotriene B4 production with an IC50 value of 0.6 µM in purified human peripheral blood polymorphonuclear leukocytes (PMNL).

Phenidone inhibited both the lipoxygenase and Cox pathways

2-(3,4-Dihydroxyphenyl)ethanol is a potent and specific inhibitor of lipoxygenase activities, inhibits platelet 12-LO activity with IC50 of 4.2 mM and PMNL 5-LO activity with IC50 of 13 mM. It's a natural product isolated and purified from the herbs of Canarium album with antioxidant property.

Wedelolactone, a natural compound derived from Chinese herbal medicine Eclipta prostrate L, is an anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα.

Osavampator是一种新型 AMPA 受体正变构调节剂，能够选择性增强学习和记忆能力，现正用于抑郁症等认知障碍的研究开发。