产品说明书

Hydroxychloroquine sulfate

Print
Chemical Structure| 747-36-4 同义名 : 硫酸羟氯喹 ;HCQ sulfate;Hydroxychloroquine (sulfate) (CRM);HCQ;NSC 4375
CAS号 : 747-36-4
货号 : A105779
分子式 : C18H28ClN3O5S
纯度 : 99%
分子量 : 433.95
MDL号 : MFCD00078203
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(241.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(230.44 mM)
动物实验配方：

PO 0.5% CMC-Na 120 mg/mL clear

生物活性
靶点

  • Autophagy
描述 Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. It is effective at inhibiting SARS-CoV-2 infection in vitro[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02603146 Healthy Participants ... 展开 >> Rheumatoid Arthritis (RA) Prevention 收起 << Phase 2 Recruiting March 2020 -
NCT01897116 Melanoma Phase 1 Completed - United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00430807 Giant Cell Arteritis Phase 3 Completed - France ... 展开 >> Hospital Agen, France, 47923 Hospital Albi, France, 81000 Hospital Auch Auch, France, 32008 Hospital Avignon Avignon, France, 84902 University Hospital Besançon Besançon, France, 25030 Hospital Béziers Beziers, France, 34525 University Hospital Côte de Nacre Caen, France, 14033 University Hospital Dijon Dijon, France, 21035 Hospital Foix, France, 09017 Hospital Lavaur, France, 81500 University Hospital Dupuytren Limoges, France, 87042 Hospital Lisieux, France, 14100 Hospital Lourdes, France, 65107 Hospital Mazamet, France, 81200 Hospital Montauban, France, 82013 University Hospital Nantes, France, 44035 Saint Louis Hospital Paris, France, 75010 University Hospital Saint Antoine Paris, France, 75012 University Hospital Bichat Paris, France, 75018 Hospital Suresnes Suresnes, France, 92151 University Hospital Toulouse Toulouse, France, 31059 University Hospital Toulouse, France, 31059 University Hospital Bretonneau Tours, France, 37044 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.52mL

2.30mL

1.15mL

23.04mL

4.61mL

2.30mL
参考文献

[1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.