HeE1-2Tyr是一种 pyridobenzothiazole 类化合物,是黄病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 的抑制剂。它在体外显著抑制西尼罗河病毒、登革热病毒和 SARS-CoV-2 的 RdRps 活性 (IC50=27.6 μM),具有抗病毒药物开发的潜力。
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描述 | HeE1-2Tyr, belonging to the pyridobenzothiazole class, serves as an inhibitor for the RNA dependent RNA polymerases (RdRp) of flaviviruses. It effectively curtails the enzymatic activity of RdRps associated with West Nile virus, Dengue virus, and SARS-CoV-2, exhibiting an in vitro IC50 value of 27.6 µM[1][2]. HeE1-2Tyr exhibits antiviral properties, effectively inhibiting a Ugandan strain of West Nile virus with an IC50 of 2.1 µM and all four serotypes of Dengue virus (DENV), with IC50 values between 6.8 and 15 µM. Its cytotoxicity against Vero E6 cells is approximately 115 µM. Furthermore, HeE1-2Tyr, when used to treat human HEK 293 cells with a CC50 of 50 µM, hinders clinical strains of yellow fever virus, with IC50 values spanning from 3.9 to 12 µM[1]. HeE1-2Tyr is capable of fully halting the replication process of both SARS-CoV-2 and Feline coronavirus (FIPV), showcasing its broad-spectrum antiviral activity[2]. |
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存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.58mL 1.72mL 0.86mL |
17.16mL 3.43mL 1.72mL |
CAS号 | 2245195-67-7 |
分子式 | C33H30N2O6S |
分子量 | 582.666 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(180.21 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |