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HeE1-2Tyr

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Chemical Structure| 2245195-67-7 同义名 : -
CAS号 : 2245195-67-7
货号 : A1550113
分子式 : C33H30N2O6S
纯度 : 98%
分子量 : 582.666
MDL号 : MFCD34574468
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(180.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 HeE1-2Tyr, belonging to the pyridobenzothiazole class, serves as an inhibitor for the RNA dependent RNA polymerases (RdRp) of flaviviruses. It effectively curtails the enzymatic activity of RdRps associated with West Nile virus, Dengue virus, and SARS-CoV-2, exhibiting an in vitro IC50 value of 27.6 µM[1][2]. HeE1-2Tyr exhibits antiviral properties, effectively inhibiting a Ugandan strain of West Nile virus with an IC50 of 2.1 µM and all four serotypes of Dengue virus (DENV), with IC50 values between 6.8 and 15 µM. Its cytotoxicity against Vero E6 cells is approximately 115 µM. Furthermore, HeE1-2Tyr, when used to treat human HEK 293 cells with a CC50 of 50 µM, hinders clinical strains of yellow fever virus, with IC50 values spanning from 3.9 to 12 µM[1]. HeE1-2Tyr is capable of fully halting the replication process of both SARS-CoV-2 and Feline coronavirus (FIPV), showcasing its broad-spectrum antiviral activity[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.58mL

1.72mL

0.86mL

17.16mL

3.43mL

1.72mL
参考文献

[1]Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235.

[2]Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.