Gallic Acid | 3,4,5-Trihydroxybenzoic acid;NSC 20103;HSDB 2117;NSC 674319 | 3,4,5-三羟基苯甲酸 | Plant Standard | Bile Acid | HDAC | ROS

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没食子酸 /Gallic Acid {[allProObj[0].p_purity_real_show]}

货号：A311911 同义名： 3,4,5-三羟基苯甲酸 / 3,4,5-Trihydroxybenzoic acid;NSC 20103

Gallic Acid是一种天然多羟基酚类化合物，具有抗菌、抗炎、抗肿瘤等活性，可通过抑制 COX-2 和清除自由基发挥抗氧化作用。

Gallic Acid 化学结构
CAS号：149-91-7

Gallic Acid 3D分子结构
CAS号：149-91-7

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Gallic Acid 纯度/质量文件产品仅供科研

货号：A311911 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

组蛋白去乙酰化酶亚型比较

产品名称	HD1 ↓ ↑	HD2 ↓ ↑	HDAC ↓ ↑	HDAC1 ↓ ↑	HDAC10 ↓ ↑	HDAC11 ↓ ↑	HDAC2 ↓ ↑	HDAC3 ↓ ↑	HDAC4 ↓ ↑	HDAC5 ↓ ↑	HDAC6 ↓ ↑	HDAC7 ↓ ↑	HDAC8 ↓ ↑	HDAC9 ↓ ↑	其他靶点	纯度
Givinostat HCl monohydrate	++++ HD1-A, IC50: 16 nM HD1-B, IC50: 7.5 nM	+++ HD2, IC50: 10 nM														99%+
MC1568	++ HD1-A (Maize), IC50: 100 nM HD1-B (Maize), IC50: 3.4 μM															96%
Trichostatin A			++++ HDAC, IC50: ~1.8 nM													99%+
Scriptaid			✔													99%+
Valproic acid sodium			✔												Autophagy	97%
AR-42			+++ HDAC, IC50: 30 nM													99%+
Dacinostat			+++ HDAC, IC50: 32 nM													98+%
CUDC-101			++++ HDAC, IC50: 4.4 nM	++++ HDAC1, IC50: 4.5 nM	+++ HDAC10, IC50: 26.1 nM		+++ HDAC2, IC50: 12.6 nM	++++ HDAC3, IC50: 9.1 nM	+++ HDAC4, IC50: 13.2 nM	+++ HDAC5, IC50: 11.4 nM	++++ HDAC6, IC50: 5.1 nM	+ HDAC7, IC50: 373 nM	++ HDAC8, IC50: 79.8 nM	++ HDAC9, IC50: 67.2 nM	HER2,EGFR	99%+
M344			++ HDAC, IC50: 100 nM													99%+
Splitomicin			+ Sir2p, IC50: 60 μM													99%
Panobinostat			++++ HDAC (MOLT-4 cells), IC50: 5 nM HDAC (Reh cells), IC50: 20 nM													98%
Sodium 4-Phenylbutyrate			✔													98%
Vorinostat			+++ HDAC, IC50: ~10 nM													98%
Curcumin			✔												Nrf2,NF-κB	98%
Belinostat			+++ HDAC, IC50: 27 nM													98%
RG-2833				++ HDAC1, Ki: 32 nM				++ HDAC3, Ki: 5 nM								98%
Valproic acid				+ HDAC1, IC50: 0.4 mM												98%
BG45				+ HDAC1, IC50: 2 μM			+ HDAC2, IC50: 2.2 μM	+ HDAC3, IC50: 289 nM								99%+
Entinostat				+ HDAC1, IC50: 0.51 μM				+ HDAC3, IC50: 1.7 μM								98%
Resminostat				+++ HDAC1, IC50: 42.5 nM				++ HDAC3, IC50: 50.1 nM			++ HDAC6, IC50: 71.8 nM					98+%
Romidepsin				+++ HDAC1, IC50: 36 nM			+++ HDAC2, IC50: 47 nM									99%+
Parthenolide				✔											p53,NF-κB	97% HPLC
Tacedinaline				+ HDAC1, IC50: 0.9 μM			+ HDAC2, IC50: 0.9 μM	+ HDAC3, IC50: 1.2 μM								98%
Mocetinostat				++ HDAC1, IC50: 0.15 μM		+ HDAC11, IC50: 0.59 μM	+ HDAC2, IC50: 0.29 μM	+ HDAC3, IC50: 1.66 μM								98%
WT-161				++++ HDAC1, IC50: 8.35 nM			+++ HDAC2, IC50: 15.4 nM				++++ HDAC6, IC50: 0.4 nM					99%+
Fimepinostat				++++ HDAC1, IC50: 1.7 nM	++++ HDAC10, IC50: 2.8 nM	++++ HDAC11, IC50: 5.4 nM	++++ HDAC2, IC50: 5.0 nM	++++ HDAC3, IC50: 1.8 nM			+++ HDAC6, IC50: 27 nM					99%+
Tucidinostat				++ HDAC1, IC50: 95 nM	++ HDAC10, IC50: 78 nM		++ HDAC2, IC50: 160 nM	++ HDAC3, IC50: 67 nM								99%+
Santacruzamate A							++++ HDAC2, IC50: 119 pM									99%+
(E,E)-RGFP966								++ HDAC3, IC50: 80 nM								99%+
LMK-235									+++ HDAC4, IC50: 11.9 nM	++++ HDAC5, IC50: 4.2 nM						99%+
Tasquinimod									✔							99%+
CAY10603											++++ HDAC6, IC50: 2 pM					98%
Tubastatin A											+++ HDAC6, IC50: 15 nM					98%
Tubacin											++++ HDAC6, IC50: 4 nM					99%+
ACY-738											++++ HDAC6, IC50: 1.7 nM					99%+
Nexturastat A											++++ HDAC6, IC50: 5 nM					99%+
BRD73954											+++ HDAC6, IC50: 36 nM		++ HDAC8, IC50: 120 nM			99%
Tubastatin A HCl											+++ HDAC6, IC50: 15 nM		+ HDAC8, IC50: 854 nM			98%
PCI-34051													+++ HDAC8, IC50: 10 nM			99%+
Ricolinostat				++ HDAC1, IC50: 58 nM			++ HDAC2, IC50: 48 nM	++ HDAC3, IC50: 51 nM			++++ HDAC6, IC50: 4.7 nM		++ HDAC8, IC50: 100 nM			99%+
Droxinostat								+ HDAC3, IC50: 16.9 μM			+ HDAC6, IC50: 2.47 μM		+ HDAC8, IC50: 1.46 μM			99%+
Abexinostat				++++ HDAC1, Ki: 7 nM	+++ HDAC10, IC50: 24 nM		+++ HDAC2, Ki: 19 nM	++++ HDAC3/SMRT, Ki: 8.2 nM			+++ HDAC6, Ki: 17 nM		+ HDAC8, IC50: 280 nM			98%+
Citarinostat				+++ HDAC1, IC50: 35 nM			+++ HDAC2, IC50: 45 nM	+++ HDAC3, IC50: 46 nM			++++ HDAC6, IC50: 2.6 nM		++ HDAC8, IC50: 137 nM			99%+
HPOB				+ HDAC1, IC50: 2.9 μM	+ HDAC10, IC50: 3.0 μM		+ HDAC2, IC50: 4.4 μM	+ HDAC3, IC50: 1.7 μM			++ HDAC6, IC50: 56 nM		+ HDAC8, IC50: 2.8 μM			97%
Quisinostat 2HCl				++++ HDAC1, IC50: 0.11 nM	++++ HDAC10, IC50: 0.46 nM	++++ HDAC11, IC50: 0.37 nM	++++ HDAC2, IC50: 0.33 nM	++++ HDAC3, IC50: 4.86 nM	++++ HDAC4, IC50: 0.64 nM	++++ HDAC5, IC50: 3.69 nM			++++ HDAC8, IC50: 4.26 nM			99+%
Domatinostat				+ HDAC1, IC50: 1.20 μM	+ HDAC10, IC50: 21 μM	+ HDAC11, IC50: 9.7 μM	+ HDAC2, IC50: 1.12 μM	+ HDAC3, IC50: 0.57 μM		+ HDAC5, IC50: 11.3 μM				+ HDAC9, IC50: 50 μM		99%+
TMP269									++ HDAC4, IC50: 157 nM	++ HDAC5, IC50: 97 nM		+++ HDAC7, IC50: 43 nM		+++ HDAC9, IC50: 23 nM		99%+
Pracinostat				++ HDAC1, IC50: 49 nM	+++ HDAC10, IC50: 40 nM	++ HDAC11, IC50: 93 nM	++ HDAC2, IC50: 96 nM	+++ HDAC3, IC50: 43 nM	++ HDAC4, IC50: 56 nM	+++ HDAC5, IC50: 47 nM	+ HDAC6, IC50: 1.008 μM	++ HDAC7, IC50: 137 nM	++ HDAC8, IC50: 140 nM	++ HDAC9, IC50: 70 nM		99%+
TMP195									++ HDAC4, Ki: 59 nM	++ HDAC5, Ki: 60 nM		+++ HDAC7, Ki: 26 nM		+++ HDAC9, Ki: 15 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Gallic Acid 生物活性

描述

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)^[3]. Gallic acid and its derivatives not only exhibit excellent antioxidant, anticarcinogenic, antimutagenic, antimicrobial properties but also provide protection to the cells against oxidative stress. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a low molecular triphenolic compound emerged as an efficient apoptosis inducing agent^[4]. Gallic acid (10 mg/kg/day) improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity^[5]. Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 mg/kg/day, p.o. LD50 of gallic acid was found to be greater than 2000 mg/kg in mice. High dose of gallic acid (900 mg/kg/day) for 28 days did not produce any significant alteration in morphological and behavioral parameters. Histopathological finding also supports safety of gallic acid in mice^[6].

Gallic Acid 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03214276	Healthy	Not Applicable	Completed	-	-
NCT03485885	-		Completed	-	Germany ... 展开 >> Nutritional CRO & Study site; BioTeSys GmbH Esslingen, Baden-Württemberg, Germany, 73728 收起 <<
NCT02273323	Vascular Function	Not Applicable	Completed	-	United Kingdom ... 展开 >> Dept Clinical Pharmacology/CRF, St Thomas Hospital London, United Kingdom, SE1 7EH 收起 <<

Gallic Acid 参考文献

[1]Choi SY, Kee HJ, et al. Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat. Biomed Pharmacother. 2018 Feb 23;101:145-154.

[2]Kang MK, Kang NJ, et al. Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. Ann N Y Acad Sci. 2009 Aug;1171:514-20.

[3]Amaravani M, Prasad NK, Ramakrishna V. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58

[4]Choubey S, Goyal S, Varughese LR, Kumar V, Sharma AK, Beniwal V. Probing Gallic Acid for Its Broad Spectrum Applications. Mini Rev Med Chem. 2018;18(15):1283-1293

[5]Bak EJ, Kim J, Jang S, Woo GH, Yoon HG, Yoo YJ, Cha JH. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14

[6]Variya BC, Bakrania AK, Madan P, Patel SS. Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice. Regul Toxicol Pharmacol. 2019 Feb;101:71-78

Gallic Acid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.88mL

1.18mL

0.59mL

29.39mL

5.88mL

2.94mL

58.78mL

11.76mL

5.88mL

Gallic Acid 技术信息

CAS号	149-91-7
分子式	C₇H₆O₅
分子量	170.119

别名	3,4,5-三羟基苯甲酸 ;3,4,5-Trihydroxybenzoic acid;NSC 20103;HSDB 2117;NSC 674319
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 105 mg/mL(617.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 8 mg/mL(47.03 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

NCT03214276	Healthy	Not Applicable	Completed	-	-
NCT03485885	-		Completed	-	Germany ... 展开 >> Nutritional CRO & Study site; BioTeSys GmbH Esslingen, Baden-Württemberg, Germany, 73728 收起 <<
NCT02273323	Vascular Function	Not Applicable	Completed	-	United Kingdom ... 展开 >> Dept Clinical Pharmacology/CRF, St Thomas Hospital London, United Kingdom, SE1 7EH 收起 <<
NCT02532088	Prediabetes	Phase 2	Not yet recruiting	September 2019	Malaysia ... 展开 >> Seberang Jaya Hospital Not yet recruiting Seberang Jaya, Penang, Malaysia, 13700 Contact: Irene Looi, MRCP, FRCP irenelooi@yahoo.com Sub-Investigator: Hock Aun Ang, MRCP, FRCP Sub-Investigator: Irene Looi, MBBS 收起 <<
NCT02328339	Vascular Function	Not Applicable	Completed	-	-
NCT02273323	-		Completed	-	-
NCT01775384	Exercise-induced Inflammation ... 展开 >> Exercise-induced Oxidative Stress Exercise-induced Immune Dysfunction 收起 <<	Not Applicable	Completed	-	United States, North Carolina ... 展开 >> ASU Human Performance Laboratory, North Carolina Research Campus Kannapolis, North Carolina, United States, 28081 收起 <<
NCT02800967	Hypertension ... 展开 >>Overweight 收起 <<	Not Applicable	Unknown	June 2017	Serbia ... 展开 >> Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade Belgrade, Serbia, 11000 收起 <<
NCT02532101	Uncontrolled Insulin-treated T... 展开 >>ype 2 Diabetes Mellitus 收起 <<	Not Applicable	Terminated(Study was terminate... 展开 >>d due to futility.) 收起 <<	-	Malaysia ... 展开 >> Seberang Jaya Hospital Seberang Jaya, Penang, Malaysia, 13700 收起 <<
NCT02227615	Absorption; Chemicals	Not Applicable	Unknown	December 2017	United States, Texas ... 展开 >> Exercise & Sport Nutrition Laboratory (ESNL) in the Department of Health and Kinesiology at Texas A&M University College station, Texas, United States, 77845 收起 <<
NCT02005939	Cardiovascular Risk Factors	Not Applicable	Completed	-	United Kingdom ... 展开 >> Queen Margaret University Edinburgh, Scotland, United Kingdom, EH21 6UU 收起 <<

没食子酸 /Gallic Acid {[allProObj[0].p_purity_real_show]}

Gallic Acid 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Gallic Acid 质控信息

Gallic Acid 生物活性

Gallic Acid 临床研究

Gallic Acid 参考文献

Gallic Acid 实验方案

Gallic Acid 技术信息

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没食子酸 /Gallic Acid {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Gallic Acid 质控信息

Gallic Acid 生物活性

Gallic Acid 临床研究

Gallic Acid 参考文献

Gallic Acid 实验方案

Gallic Acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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