Gallic Acid

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Chemical Structure| 149-91-7 同义名 : 3,4,5-三羟基苯甲酸 ;3,4,5-Trihydroxybenzoic acid;NSC 20103;HSDB 2117;NSC 674319
CAS号 : 149-91-7
货号 : A311911
分子式 : C7H6O5
纯度 : 98%
分子量 : 170.119
MDL号 : MFCD00002510
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(617.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 8 mg/mL(47.03 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[3]. Gallic acid and its derivatives not only exhibit excellent antioxidant, anticarcinogenic, antimutagenic, antimicrobial properties but also provide protection to the cells against oxidative stress. Gallic acid (3, 4, 5-trihydroxybenzoic acid), a low molecular triphenolic compound emerged as an efficient apoptosis inducing agent[4]. Gallic acid (10 mg/kg/day) improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity[5]. Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 mg/kg/day, p.o. LD50 of gallic acid was found to be greater than 2000 mg/kg in mice. High dose of gallic acid (900 mg/kg/day) for 28 days did not produce any significant alteration in morphological and behavioral parameters. Histopathological finding also supports safety of gallic acid in mice[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03214276 Healthy Not Applicable Completed - -
NCT03485885 - Completed - Germany ... 展开 >> Nutritional CRO & Study site; BioTeSys GmbH Esslingen, Baden-Württemberg, Germany, 73728 收起 <<
NCT02273323 Vascular Function Not Applicable Completed - United Kingdom ... 展开 >> Dept Clinical Pharmacology/CRF, St Thomas Hospital London, United Kingdom, SE1 7EH 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.88mL

1.18mL

0.59mL

29.39mL

5.88mL

2.94mL

58.78mL

11.76mL

5.88mL
参考文献

[1]Choi SY, Kee HJ, et al. Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat. Biomed Pharmacother. 2018 Feb 23;101:145-154.

[2]Kang MK, Kang NJ, et al. Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2. Ann N Y Acad Sci. 2009 Aug;1171:514-20.

[3]Amaravani M, Prasad NK, Ramakrishna V. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58

[4]Choubey S, Goyal S, Varughese LR, Kumar V, Sharma AK, Beniwal V. Probing Gallic Acid for Its Broad Spectrum Applications. Mini Rev Med Chem. 2018;18(15):1283-1293

[5]Bak EJ, Kim J, Jang S, Woo GH, Yoon HG, Yoo YJ, Cha JH. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14

[6]Variya BC, Bakrania AK, Madan P, Patel SS. Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice. Regul Toxicol Pharmacol. 2019 Feb;101:71-78