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GLPG0634 analog

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Chemical Structure| 1206101-20-3 同义名 : GLPG0634 analogue
CAS号 : 1206101-20-3
货号 : A467951
分子式 : C23H18N6O2
纯度 : 99%+
分子量 : 410.428
MDL号 : MFCD26406012
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(121.82 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • JAK2
描述 GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02885181 Rheumatoid Arthritis Phase 2 Completed - United States, Florida ... 展开 >> Omega Research Consultants DeBary, Florida, United States, 32713 Sarasota Arthritis Research Center Sarasota, Florida, United States, 34239 United States, Georgia Medical Associates of North Georgia Canton, Georgia, United States, 30114 United States, Kentucky Center For Arthritis and Osteoporosis Elizabethtown, Kentucky, United States, 42701 United States, New Mexico Albuquerque Center For Rheumatology Albuquerque, New Mexico, United States, 87102 United States, Pennsylvania Altoona Center for Clinical Research Duncansville, Pennsylvania, United States, 16635 United States, Texas Accurate Clinical Management - Najam Houston, Texas, United States, 77084 Accurate Clinical Research Inc. Stafford, Texas, United States, 77477 Medical Center Research LLC Webster, Texas, United States, 77598 Bulgaria MHAT-Plovdiv AD Plovdiv, Bulgaria, 4000 Umhat Kaspela Plovdiv, Bulgaria, 4003 NMTH Tsar Boris III Sofia, Bulgaria, 1233 Czechia A-Shine s.r.o. Plzen, Czechia, 31200 Medical Plus, S.R.O. Uherske Hradiste, Czechia, 68601 Georgia LLC Arensia Exploratory Medicine T'bilisi, Georgia, 0112 Moldova, Republic of ARENSIA Exploratory Medicine Phase I Unit, Republican Clinical Hospital Chisinau, Moldova, Republic of, MD-2025 Poland ClinicMed Badurski i wspolnicy Spolka Jawna Bialystok, Poland, 15-879 Ukraine Kharkiv City Hospital 8 Kharkiv, Ukraine, 140176 Medical Center_Clinic of International Institute of clinical Studies Kyiv, Ukraine, 2068 收起 <<
NCT02885181 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.36mL

4.87mL

2.44mL
参考文献

[1]Van Rompaey L, Galien R, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013 Oct 1;191(7):3568-77.