There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Edoxaban tosylate monohydrate is an orally active, potent, selective and direct FXa inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and thrombin, and is more than 10,000-fold selective for free human FXa and thrombomodulin over other thrombin enzymes.Edoxaban tosylate monohydrate is used in thromboembolic disease prevention studies. Edoxaban tosylate monohydrate is used in studies for the prevention of thromboembolic diseases.Edoxaban tosylate monohydrate prolongs human plasma PT, TT, and APTT in a concentration-dependent manner[1].
Edoxaban tosylate monohydrate 动物研究
Animal study
Administered as a single oral dose at 0.5, 2.5 and 12.5 mg/kg, Edoxaban tosylate monohydrate inhibited exogenous FXa activity, significantly and dose-dependently reducing thrombosis and prolonging PT in a venous stasis thrombosis model in Wistar rats and male New Zealand White rabbits[1].
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