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Edoxaban tosylate monohydrate

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Chemical Structure| 1229194-11-9 同义名 : DU-176b monohydrate;DU-176b
CAS号 : 1229194-11-9
货号 : A2667461
分子式 : C31H40ClN7O8S2
纯度 : 99%
分子量 : 738.274
MDL号 : MFCD28400751
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(67.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(1.35 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • Factor Xa

    Factor Xa, Ki:0.561 nM
描述 Edoxaban tosylate monohydrate is an orally active, potent, selective and direct FXa inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and thrombin, and is more than 10,000-fold selective for free human FXa and thrombomodulin over other thrombin enzymes.Edoxaban tosylate monohydrate is used in thromboembolic disease prevention studies. Edoxaban tosylate monohydrate is used in studies for the prevention of thromboembolic diseases.Edoxaban tosylate monohydrate prolongs human plasma PT, TT, and APTT in a concentration-dependent manner[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.77mL

1.35mL

0.68mL

13.55mL

2.71mL

1.35mL
参考文献

[1]Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.