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/ Dexamethasone 21-Acetate

醋酸地塞米松 /Dexamethasone 21-Acetate {[allProObj[0].p_purity_real_show]}

货号：A624126 同义名： 乙酸地塞米松 / Hexadecadrol acetate;Dexamethasone acetate

Dexamethasone Acetate is a synthetic glucocorticoid which works as a glucocorticoid receptor agonist and an interleukin receptor modulator.

Dexamethasone 21-Acetate 化学结构 CAS号：1177-87-3
Dexamethasone 21-Acetate 化学结构
CAS号：1177-87-3
Dexamethasone 21-Acetate 3D分子结构
CAS号：1177-87-3
Dexamethasone 21-Acetate 化学结构 CAS号：1177-87-3
Dexamethasone 21-Acetate 3D分子结构 CAS号：1177-87-3
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Dexamethasone 21-Acetate 纯度/质量文件 产品仅供科研

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Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Dexamethasone 21-Acetate 生物活性

描述 Protein-1, nuclear factor-AT, and nuclear factor-kB are involved in both activating and repressing crucial genes associated with the inflammatory response[1] Dexamethasone strongly inhibits GM-CSF release from A549 cells with an EC50 of 2.2 nM and induces β2-receptor transcription at significantly higher concentrations (EC50=36 nM), correlating with glucocorticoid receptor (GR) DNA binding. Additionally, Dexamethasone (IC50=0.5 nM) targets a 3×κB complex involved in inhibiting GM-CSF release[2].
体内研究

A single dose of Dexamethasone (10 mg/kg, i.p.) significantly reduces granulocyte recruitment and spontaneous oxygen radical production compared to LPS-exposed animals treated with saline[3].

Rats receiving Dexamethasone consume less food and exhibit a lower body weight than controls. Despite similar food intake, these rats weigh less than pair-fed animals. Five days of Dexamethasone injections significantly increase liver mass by 42% and the liver-to-body weight ratio by 65%. The gastrocnemius muscle's wet weight decreases by 20% after five days of treatment, paralleling the overall body weight loss[4].
体外研究

Protein-1, nuclear factor-AT, and nuclear factor-kB are involved in both activating and repressing crucial genes associated with the inflammatory response[1]

Dexamethasone strongly inhibits GM-CSF release from A549 cells with an EC50 of 2.2 nM and induces β2-receptor transcription at significantly higher concentrations (EC50=36 nM), correlating with glucocorticoid receptor (GR) DNA binding. Additionally, Dexamethasone (IC50=0.5 nM) targets a 3×κB complex involved in inhibiting GM-CSF release[2].

Dexamethasone 21-Acetate 动物研究

Dose Horse: 83 μg/kg[3] (i.m.) Rat: 0.527 μg/kg[3] (p.o.) Cow: 40 μg/kg[3] (i.v.)
Administration i.m., p.o., i.v.

Dexamethasone 21-Acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03283046 Malignant Neoplasms Stated as ... 展开 >>Primary Lymphoid Haematopoietic Multiple Myeloma 收起 << Phase 1 Withdrawn(Similar to another s... 展开 >>tudy.) 收起 << October 2020 -
NCT03740659 Cataract Phase 2 Recruiting March 2019 Italy ... 展开 >> ASST Santi Paolo e Carlo di Milano - P.O. San Paolo di Milano Recruiting Milano, MI, Italy, 20142 Contact: Luca Rossetti, Prof.    +390250323150    luca.rossetti@unimi.it    Principal Investigator: Luca Rossetti, Prof.          A.O.U. Pisana - P.O. di Cisanello Recruiting Pisa, PI, Italy, 56124 Contact: Marco Nardi, Prof.       marco.nardi@med.unipi.it    Principal Investigator: Marco Nardi, Prof. 收起 <<
NCT03122756 Cesarean Section Early Phase 1 Recruiting October 2018 Egypt ... 展开 >> Ain Shams Maternity Hospital Recruiting Cairo, Egypt Contact: Mahmoud AA ElShourbagy, MD    +201001448189    elshourbagym22@hotmail.com 收起 <<

Dexamethasone 21-Acetate 参考文献

[1]LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.

[2]Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11

[3]Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56

[4]Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9.

Dexamethasone 21-Acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.51mL

2.30mL

1.15mL

23.02mL

4.60mL

2.30mL

Dexamethasone 21-Acetate 技术信息

CAS号1177-87-3
分子式C24H31FO6
分子量 434.498
别名 乙酸地塞米松 ;Hexadecadrol acetate;Dexamethasone acetate;NSC 39471
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度

DMSO: 50 mg/mL(115.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Dexamethasone 21-Acetate |醋酸地塞米松 | 乙酸地塞米松 | Hexadecadrol acetate | Dexamethasone acetate | NSC 39471 | 1177-87-3 | IL Receptor | 自噬 | 孕激素 | 糖皮质激素受体 | Dexamethasone 21-Acetate 纯度/质量文件 | Dexamethasone 21-Acetate 亚型比较 | Dexamethasone 21-Acetate 生物活性 | Dexamethasone 21-Acetate 动物研究 | Dexamethasone 21-Acetate 临床数据 | Dexamethasone 21-Acetate 参考文献 | Dexamethasone 21-Acetate 实验方案 | Dexamethasone 21-Acetate 技术信息

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