产品说明书
Dexamethasone 21-Acetate
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同义名 : | 乙酸地塞米松 ;Hexadecadrol acetate;Dexamethasone acetate;NSC 39471 |
| CAS号 : | 1177-87-3 | |
| 货号 : | A624126 | |
| 分子式 : | C24H31FO6 | |
| 纯度 : | 98% | |
| 分子量 : | 434.498 | |
| MDL号 : | MFCD00027407 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(115.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Protein-1, nuclear factor-AT, and nuclear factor-kB are involved in both activating and repressing crucial genes associated with the inflammatory response[1] Dexamethasone strongly inhibits GM-CSF release from A549 cells with an EC50 of 2.2 nM and induces β2-receptor transcription at significantly higher concentrations (EC50=36 nM), correlating with glucocorticoid receptor (GR) DNA binding. Additionally, Dexamethasone (IC50=0.5 nM) targets a 3×κB complex involved in inhibiting GM-CSF release[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03283046 | Malignant Neoplasms Stated as ... 展开 >>Primary Lymphoid Haematopoietic Multiple Myeloma 收起 << | Phase 1 | Withdrawn(Similar to another s... 展开 >>tudy.) 收起 << | October 2020 | - |
| NCT03740659 | Cataract | Phase 2 | Recruiting | March 2019 | Italy ... 展开 >> ASST Santi Paolo e Carlo di Milano - P.O. San Paolo di Milano Recruiting Milano, MI, Italy, 20142 Contact: Luca Rossetti, Prof. +390250323150 luca.rossetti@unimi.it Principal Investigator: Luca Rossetti, Prof. A.O.U. Pisana - P.O. di Cisanello Recruiting Pisa, PI, Italy, 56124 Contact: Marco Nardi, Prof. marco.nardi@med.unipi.it Principal Investigator: Marco Nardi, Prof. 收起 << |
| NCT03122756 | Cesarean Section | Early Phase 1 | Recruiting | October 2018 | Egypt ... 展开 >> Ain Shams Maternity Hospital Recruiting Cairo, Egypt Contact: Mahmoud AA ElShourbagy, MD +201001448189 elshourbagym22@hotmail.com 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.30mL 0.46mL 0.23mL |
11.51mL 2.30mL 1.15mL |
23.02mL 4.60mL 2.30mL |
| 参考文献 |
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