货号:A506283 同义名: 6-Nitroveratraldehyde;NSC 65590
DMNB is a volatile organic compound used as a detection taggant for explosives.
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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
产品名称 | DNA-PK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PI-103 |
++
DNA-PK, IC50: 23 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CC-115 |
+++
DNA-PK, IC50: 0.013 μM |
mTOR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Samotolisib | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
NU 7026 |
+
DNA-PK, IC50: 0.23 μM |
PI3K | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PIK-75 HCl |
++++
DNA-PK, IC50: 2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PP121 |
+
DNA-PK, IC50: 60 nM |
PDGFR,VEGFR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
KU-0060648 |
++++
DNA-PK, IC50: 5 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
KU-57788 |
+++
DNA-PK, IC50: 14 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
LTURM34 |
++
DNA-PK, IC50: 0.034 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SF2523 |
+++
DNA-PK, IC50: 9 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Dimethoxy-2-nitrobenzyl adenosine-3',5' cyclic monophosphate (DMNB) is a metabolically active, photolabile cyclic AMP analog that yields free cyclic AMP upon UV hydrolysis. The analog is useful in that it permits short term, transient elevations of intracellular cyclic AMP. Addition of DMNB (1-10 microM) to mouse mammary epithelial cells, followed by UV irradiation of cells, caused a significant increase in DNA synthesis over that observed with controls, UV irradiation alone or DMNB alone[2]. HA-DMNB (hyaluronan) is more resistant to hyaluronidase than HA, and HA-DMNB could release free carboxyl groups of HA upon ultraviolet to bond with H2O. More importantly, HA-DMNB was protective against UV light[3]. Moreover, a photocaged derivative (HP-DMNB) of HP (Heparin) was synthesized for light control of its anticoagulant activity. The synthesized HP-DMNB was characterized by NMR and FTIR analysis, which confirmed the successful modification of HP with the photocleavable 4,5-dimethoxyl-2-nitrobenzyl (DMNB) groups. After the modification, the molecular weight of HP-DMNB (DS = 0.34%) changed from 61 to 71 kDa. Anticoagulant activity analysis showed that HP-DMNB had a reduced anticoagulant capacity compared with commercial HP, while its anticoagulant activity will regain after releasing the free carboxyl groups of HP under UV light[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.74mL 0.95mL 0.47mL |
23.68mL 4.74mL 2.37mL |
47.36mL 9.47mL 4.74mL |
CAS号 | 20357-25-9 |
分子式 | C9H9NO5 |
分子量 | 211.172 |
别名 | 6-Nitroveratraldehyde;NSC 65590 |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(497.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |