DIM-C-pPhOH | Apoptosis Inducer | Nur77 | AmBeed-信号通路专用抑制剂

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DIM-C-pPhOH {[allProObj[0].p_purity_real_show]}

货号：A386994

DIM-C-pPhOH is Nur77 antagonist which can induce conformational change.

DIM-C-pPhOH 化学结构
CAS号：151358-47-3

DIM-C-pPhOH 3D分子结构
CAS号：151358-47-3

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DIM-C-pPhOH 纯度/质量文件产品仅供科研

货号：A386994 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

DIM-C-pPhOH 生物活性

描述

The orphan nuclear receptor NR4A1 (nuclear receptor 4A1) exhibits pro-oncogenic activity in cancer cell lines. NR4A1 activates mTOR signaling, regulates genes such as thioredoxin domain containing 5 and isocitrate dehydrogenase 1 that maintain low oxidative stress, and coactivates specificity protein 1 (Sp1)-regulated pro-survival and growth promoting genes. DIM-C-pPhOH binds NR4A1 and act as antagonists. DIM-C-pPhOH (20 μM; 18 hr) inhibited growth and induced apoptosis in ACHN and 786-O cells, and the functional and genomic effects of it were comparable to those observed after NR4A1 knockdown. Moreover, treatment of these cells with 0–20 μM of the NR4A1 antagonist DIM-C-pPhOH also significantly decreased cell proliferation. IC₅₀ values for DIM-C-pPhOH were 13.6 μM and 13.0 μM in ACHN cells and 786-O cells, respectively. Moreover, treatment of athymic nude mice bearing ACHN cells as xenografts with DIM-C-pPhOH (30 mg/kg/d) for 50 days also resulted in a significant inhibition of tumor growth and complemented results of the in vitro studies. In addition, researchers also observed decreased expression of survivin, bcl-2, EGFR and induced PARP cleavage in tumor lysates from nude mice bearing ACHN cells as a xenograft and treated with DIM-C-pPhOH (30 mg/kg/d)^[1].

DIM-C-pPhOH 参考文献

[1]Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma

DIM-C-pPhOH 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.55mL

5.91mL

2.96mL

DIM-C-pPhOH 技术信息

CAS号	151358-47-3
分子式	C₂₃H₁₈N₂O
分子量	338.402

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 120 mg/mL(354.61 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

DIM-C-pPhOH {[allProObj[0].p_purity_real_show]}

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DIM-C-pPhOH 质控信息

DIM-C-pPhOH 生物活性

DIM-C-pPhOH 参考文献

DIM-C-pPhOH 实验方案

DIM-C-pPhOH 技术信息

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DIM-C-pPhOH 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

DIM-C-pPhOH 质控信息

DIM-C-pPhOH 生物活性

DIM-C-pPhOH 参考文献

DIM-C-pPhOH 实验方案

DIM-C-pPhOH 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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DIM-C-pPhOH 纯度/质量文件产品仅供科研