DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

Cytosporone B is a Nur77 agonist with EC50 of 0.278 nM. It inhibits cancer cell proliferation and tumor growth.

TMPA is an antagonist of nuclear receptor Nur77 and LKB1 interaction.

DIM-C-pPhOH is Nur77 antagonist which can induce conformational change.

DIM-C-pPhCO2Me is a NR4A1 antagonist.

Isofangchinoline is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra, which may be an inactivator of nuclear NR4A1, as well as inhibited cell proliferation and induced apoptosis in human pancreatic cancer cells.

THPNis a Nur77 agonist that induces autophagy in melanoma cell lines.