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DCPIB {[allProObj[0].p_purity_real_show]}

货号:A1176584

DCPIB是一种体积调节性阴离子通道(VRAC)抑制剂,能有效抑制细胞的钠钾通道和氯电流。它在细胞肿胀和离子通道研究中具有应用潜力。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
DCPIB 化学结构 CAS号:82749-70-0
DCPIB 化学结构
CAS号:82749-70-0
DCPIB 3D分子结构
CAS号:82749-70-0
DCPIB 化学结构 CAS号:82749-70-0
DCPIB 3D分子结构 CAS号:82749-70-0
规格 价格 会员价 库存 数量
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DCPIB 纯度/质量文件 产品仅供科研

货号:A1176584 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Potassium Channel 其他靶点 纯度
Tolbutamide 98%
Glimepiride ++++

SUR2B, IC50: 7.3 nM

SUR1, IC50: 5.4 nM

97%
Dronedarone Hydrochloride 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

98%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

98%
Glibenclamide 98%
Amiodarone HCl 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

98%
Repaglinide 98%
Dofetilide 98%
Nateglinide 99%
Quinine hydrochloride dihydrate 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

DCPIB 生物活性

描述 DCPIB is a selective, reversible and potent inhibitor of VRAC. DCPIB voltage-dependently activates the potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1, and TASK3 (IC50 values of 0.14, 0.95, and 50.72 μM, respectively). DCPIB is also a selective and swelling-induced blocker of chloride current with an IC50 value of 4.1 μM. DCPIB is an effective tool to study the structure-function of K2P channels. DCPIB at a concentration of 10 μM activates TREK1 and enhances TRAAK currents in COS-7 cells[1][2]. At the same concentration, DCPIB significantly and reversibly inhibited TRESK current in COS-7 cells with an IC50 of 0.14 μM[1]. While acting for 3 hours, DCPIB inhibited LPS-induced MAPK activation in BV2 cells[3].

DCPIB 参考文献

[1]Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.

[2]Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.

[3]Han Q, Liu S, Li Z, Hu F, Zhang Q, Zhou M, Chen J, Lei T, Zhang H. DCPIB, a potent volume-regulated anion channel antagonist, attenuates microglia-mediated inflammatory response and neuronal injury following focal cerebral ischemia. Brain Res. 2014 Jan 13;1542:176-85. doi: 10.1016/j.brainres.2013.10.026. Epub 2013 Nov 1. PMID: 24189520.

DCPIB 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.34mL

0.47mL

0.23mL

11.70mL

2.34mL

1.17mL

23.40mL

4.68mL

2.34mL

DCPIB 技术信息

CAS号82749-70-0
分子式C22H28Cl2O4
分子量 427.361
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(245.69 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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