产品说明书
DCPIB
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同义名 : | - |
| CAS号 : | 82749-70-0 | |
| 货号 : | A1176584 | |
| 分子式 : | C22H28Cl2O4 | |
| 纯度 : | 99% | |
| 分子量 : | 427.361 | |
| MDL号 : | MFCD07783995 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(245.69 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | DCPIB is a selective, reversible and potent inhibitor of VRAC. DCPIB voltage-dependently activates the potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1, and TASK3 (IC50 values of 0.14, 0.95, and 50.72 μM, respectively). DCPIB is also a selective and swelling-induced blocker of chloride current with an IC50 value of 4.1 μM. DCPIB is an effective tool to study the structure-function of K2P channels. DCPIB at a concentration of 10 μM activates TREK1 and enhances TRAAK currents in COS-7 cells[1][2]. At the same concentration, DCPIB significantly and reversibly inhibited TRESK current in COS-7 cells with an IC50 of 0.14 μM[1]. While acting for 3 hours, DCPIB inhibited LPS-induced MAPK activation in BV2 cells[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.34mL 0.47mL 0.23mL |
11.70mL 2.34mL 1.17mL |
23.40mL 4.68mL 2.34mL |
| 参考文献 |
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