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Curcumin

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Chemical Structure| 458-37-7 同义名 : Diferuloylmethane;Natural Yellow 3;UNIIIT942ZTH98.;NSC32982;C.I. 75300;curcumin I;Indian Saffron;Turmeric yellow
CAS号 : 458-37-7
货号 : A147405
分子式 : C21H20O6
纯度 : 98%
分子量 : 368.38
MDL号 : MFCD00008365
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(285.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5%DMSO+10%PEG300+5%Tween80+80%water 4 mg/mL

生物活性
靶点

  • p300/CBP

    p300, IC50:~25 μM

  • HDAC

  • NF-κB
描述 Curcumin, a polyphenol found in turmeric (curcuma longa), has health benefits such as antioxidant, anti-inflammatory, and anticancer properties, improvement of brain function, and control of obesity and diabetes. And dietary curcumin (80 mg kg−1) administered to mice on a high-fat diet significantly lowered the fasting blood glucose levels and TNF-α concentrations, and inhibited the lowering of glucose tolerance[3]. Moreover, cur(curcumin) inhibited hypoxia-induced HIF1α expression and tissue damage by demonstrating the improved morphology of astrocytes and remarkable reduction in vacuolation[4].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
human A549 cells Proliferation assay 72 h Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=17.3 μM 24280069
human Jurkat cells Proliferation assay 72 h Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay, IC50=4.29 μM 24280069
human KBM5 cells Proliferation assay 72 h Antiproliferative activity against human KBM5 cells after 72 hrs by MTT assay, IC50=3.84 μM 24280069
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.57mL

2.71mL

1.36mL

27.15mL

5.43mL

2.71mL
参考文献

[1]Cao A, Li Q, et al. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Nov;18(11):1391-402.

[2]Gao S, Duan X, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Sep;59:739-47.

[3]Tsuda T . Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food Funct. 2018 Feb 21;9(2):705-714. doi: 10.1039/c7fo01242j. PMID: 29206254.

[4]Daverey A, Agrawal SK. Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk. J Neurotrauma. 2020 May 15;37(10):1255-1265. doi: 10.1089/neu.2019.6749. Epub 2020 Feb 5. PMID: 31914858.