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胆固醇 /Cholesterol {[allProObj[0].p_purity_real_show]}

货号：A612467 同义名： 胆甾醇 / N-Octadecanoyl-monosialoganglioside GM1 (NH4+salt);Cholesterin

Cholesterol是哺乳动物中的主要固醇，在膜的流动性和信号传导中发挥重要作用，同时也是 ERRα 的内源性激动剂，用于代谢和细胞信号研究。

Cholesterol 化学结构 CAS号：57-88-5
Cholesterol 化学结构
CAS号：57-88-5
Cholesterol 3D分子结构
CAS号：57-88-5
Cholesterol 化学结构 CAS号：57-88-5
Cholesterol 3D分子结构 CAS号：57-88-5
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Cholesterol 纯度/质量文件 产品仅供科研

货号：A612467 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]
• Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]
• ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]
• ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]
• Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]
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Cholesterol 生物活性

描述 Cholesterol, as a kind of the oxidizable lipids, is an agent of biomembranes and plasma lipoproteinsis. In vitro studies, cholesterol could impact the function and inhibition of multidrug resistance P-glycoprotein (Pgp) in NIH 3T3 cells , through some special substrate and cell-type-specific manners. In vivo studies, it was found that dietary cholesterol could increase plasma lipoprotein concentrations in adult baboons, as well as suppress the activity of hepatic sterol 27-hydroxylase in baboons. Besides this, maternal cholesterol could also strengthen the movement of cholesterol down a concentration gradient in the placenta , lipoprotein secretion from the yolk sac (shown previously) and possibly placental NPC1L1 expression in the golden Syrian hamster.

Cholesterol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01156597 - Completed - -
NCT02534376 Prostate Cancer Early Phase 1 Recruiting February 2020 United States, California ... 展开 >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Jenny Park, MPH    310-423-8762    jenny.park@cshs.org    Principal Investigator: Hyung L Kim, MD 收起 <<
NCT01156597 Type 2 Diabetes Mellitus Phase 3 Completed - United States, Florida ... 展开 >> Diabetes Research Institute Miami, Florida, United States, 33136 收起 <<

Cholesterol 参考文献

[1]Terao J. Cholesterol hydroperoxides and their degradation mechanism. Subcell Biochem. 2014.

[2]Luker GD, Pica CM, et al. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 2000;39(26):7651-61.

[3]Mott GE, Jackson EM, et al. Dietary cholesterol and type of fat differentially affect cholesterol metabolism and atherosclerosis in baboons. J Nutr. 1992;122(7):1397-406.

[4]Kushwaha RS, Guntupalli B, et al. Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). Arterioscler Thromb Vasc Biol. 1995;15(9):1404-11.

[5]Burke KT, Colvin PL, et al. Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. J Lipid Res. 2009;50(6):1146-55.

Cholesterol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.93mL

2.59mL

1.29mL

25.86mL

5.17mL

2.59mL

Cholesterol 技术信息

CAS号57-88-5
分子式C27H46O
分子量 386.654
别名 胆甾醇 ;N-Octadecanoyl-monosialoganglioside GM1 (NH4+salt);Cholesterin;NSC 8798;HSDB 7106;CCRIS2834 CCRIS-2834;AI3 03112 CCRIS 2834;AI3-03112;N-Stearoyl GM1;N-C18:0 GM1
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解度

无水乙醇: 20 mg/mL(51.73 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Cholesterol | N-Octadecanoyl-monosialoganglioside GM1 (NH4+salt);Cholesterin;NSC 8798;HSDB 7106;CCRIS2834 CCRIS-2834;AI3 03112 CCRIS 2834;AI3-03112;N-Stearoyl GM1;N-C18:0 GM1 | 胆甾醇 | Additive and Auxiliary Reagent | Medicinal Excipient | Plant Standard | Cholestane | AmBeed-信号通路专用抑制剂 | Cholesterol 纯度/质量文件 | Cholesterol 生物活性 | Cholesterol 临床数据 | Cholesterol 参考文献 | Cholesterol 实验方案 | Cholesterol 技术信息

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