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Cholesterol

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Chemical Structure| 57-88-5 同义名 : 胆甾醇 ;N-Octadecanoyl-monosialoganglioside GM1 (NH4+salt);Cholesterin;NSC 8798;HSDB 7106;CCRIS2834 CCRIS-2834;AI3 03112 CCRIS 2834;AI3-03112;N-Stearoyl GM1;N-C18:0 GM1
CAS号 : 57-88-5
货号 : A612467
分子式 : C27H46O
纯度 : 98%
分子量 : 386.654
MDL号 : MFCD00003646
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

无水乙醇: 20 mg/mL(51.73 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Cholesterol, as a kind of the oxidizable lipids, is an agent of biomembranes and plasma lipoproteinsis. In vitro studies, cholesterol could impact the function and inhibition of multidrug resistance P-glycoprotein (Pgp) in NIH 3T3 cells , through some special substrate and cell-type-specific manners. In vivo studies, it was found that dietary cholesterol could increase plasma lipoprotein concentrations in adult baboons, as well as suppress the activity of hepatic sterol 27-hydroxylase in baboons. Besides this, maternal cholesterol could also strengthen the movement of cholesterol down a concentration gradient in the placenta , lipoprotein secretion from the yolk sac (shown previously) and possibly placental NPC1L1 expression in the golden Syrian hamster.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01156597 - Completed - -
NCT02534376 Prostate Cancer Early Phase 1 Recruiting February 2020 United States, California ... 展开 >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Jenny Park, MPH    310-423-8762    jenny.park@cshs.org    Principal Investigator: Hyung L Kim, MD 收起 <<
NCT01156597 Type 2 Diabetes Mellitus Phase 3 Completed - United States, Florida ... 展开 >> Diabetes Research Institute Miami, Florida, United States, 33136 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.93mL

2.59mL

1.29mL

25.86mL

5.17mL

2.59mL
参考文献

[1]Terao J. Cholesterol hydroperoxides and their degradation mechanism. Subcell Biochem. 2014.

[2]Luker GD, Pica CM, et al. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 2000;39(26):7651-61.

[3]Mott GE, Jackson EM, et al. Dietary cholesterol and type of fat differentially affect cholesterol metabolism and atherosclerosis in baboons. J Nutr. 1992;122(7):1397-406.

[4]Kushwaha RS, Guntupalli B, et al. Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). Arterioscler Thromb Vasc Biol. 1995;15(9):1404-11.

[5]Burke KT, Colvin PL, et al. Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. J Lipid Res. 2009;50(6):1146-55.