CNQX Disodium Salt is a AMPA/kainate antagonist and also available as part of the Kainate Receptor.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
CNQX disodium (FG9065 disodium), a potent and competitive AMPA/kainate receptor antagonist, displays IC50s of 0.3 μM and 1.5 μM, respectively, functioning as a competitive non-NMDA receptor antagonist[1]. CNQX disodium suppresses the expression of fear-potentiated startle in rats[5].
体内研究
CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) diminishes the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
Bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min before a retention test partially impedes the expression of stepdown inhibitory avoidance in rats 24 h after training. Complete blockade is achieved with a dose of 0.5 μg[5].
体外研究
CNQX disodium (FG9065 disodium; 2-5 μM) reversibly inhibits the Schaffer collateral and mossy fiber excitatory postsynaptic potential (EPSP) while preserving fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX disodium (1-5 μM) induces a selective and dose-dependent decrease in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].
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