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CNQX disodium

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Chemical Structure| 479347-85-8 同义名 : FG9065 disodium
CAS号 : 479347-85-8
货号 : A814876
分子式 : C9H2N4Na2O4
纯度 : 99%+
分子量 : 276.116
MDL号 : MFCD00801053
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(32.59 mM)，配合低频超声，水浴加热至45℃，并调节pH至2，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CNQX disodium (FG9065 disodium), a potent and competitive AMPA/kainate receptor antagonist, displays IC50s of 0.3 μM and 1.5 μM, respectively, functioning as a competitive non-NMDA receptor antagonist[1]. CNQX disodium suppresses the expression of fear-potentiated startle in rats[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.11mL

3.62mL

1.81mL

36.22mL

7.24mL

3.62mL
参考文献

[1]Aqeel Imran, et al. Development, Molecular Docking, and In Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the Polyol Pathway. ACS Omega 2022.

[2]Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8.

[3]Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302.

[4]Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb;166(1):69-76.

[5]Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8.