宝藿苷 I /Baohuoside I {[allProObj[0].p_purity_real_show]}
货号：A114553同义名：
Icariin-II;Icariside-II
Baohuoside I, a flavonoid, acts as an apoptosis inducer and a down-regulator of durvivin and cyclin D1 expression. It is used as an anti-cancer agent and can be isolated and purified from the roots of epimedium brevicornu Maxim.
Baohuoside I, a flavonoid isolated from Epimedium koreanum Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 expression, induces apoptosis and shows anti-tumor activity.
体内研究
At a dosage of 25 mg/kg, Baohuoside I reduces β-catenin protein levels and the expression of cyclin D1 and survivin in nude mice[3].
体外研究
Baohuoside I is an inhibitor of CXCR4, and downregulates CXCR4 expression at 12-25 μM. Baohuoside I (0-25 μM) suppresses NF-κB activation in a dose-dependent manner, suppresses CXCL12 induced the invasion of cervical cancer cells. Baohuoside I also inhibits invasion of breast cancer cells[1].
Baohuoside I curtails the viability of A549 cells, with IC50 values of 25.1 μM at 24 hours, 11.5 μM at 48 hours, and 9.6 μM at 72 hours. At a concentration of 25 μM, it inhibits the caspase cascade, increases ROS levels, and triggers the JNK and p38MAPK signaling pathways in A549 cells[2].
Baohuoside I (3.125, 6.25, 12.5, 25.0 and 50.0 µg/mL) significantly and dose-dependently blocks the growth of esophageal squamous cell carcinoma Eca109 cells, with an IC50 of 4.8 µg/mL at 48 h[3].
Tags:
Baohuoside I | Icariin-II;Icariside-II | Apoptosis Inducer | Plant Standard | CXCR | AmBeed-信号通路专用抑制剂
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