Through binding with CC- and CXC-chemokines, CCR and CXCR, the subsets of the chemokine receptor family can trigger an intracellular signal transduction cascade, thus mediating the recruitment of immune cells to the in£ammation or infection sites and implicated in several immuno-related disease states, organogenesis, angiogenesis and tumor growth and metastasis. AMD3100 is a selective antagonist of CXCR4 with IC50 values ranging in 0.01-0.13μg/ml for antagonizing SDF-1, but not itself, activated calcium flux in different cells tested, including CXCR4-transfected U87 and CD4 cells, freshly isolated PBMCs, SupT1, THP-1, HSB-2, Molt-4 and L1210 cells. The inhibitory effect of AMD3100 against the induced endocytosis of CXCR4 is selectively SDF-1-dependent but not phorbol ester. Pre-incubated with AMD3100 at concentration of 0.04, 0.2, 1, 5 and 25μg/ml could dose-dependently inhibit the SDF-1-induced (200 ng/ml) chemotaxis of human PBMCs[1]. In vivo study showed that intraperitoneal injection with 5mg/kg AMD3100 can alter the potential of mesenchymal stem cells mobilization induced by different growth factors, including IGF-1, SCF, PDGF and VEGF, in mice, which may be mediated through Akt/PI3K, MEK1/2-Erk1/2 and smad2/3 as key signaling pathways[2].
作用机制
Not found
Plerixafor 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
CEM-SS cells
Function assay
Effective concentration of compound against HIV-1 LAI strain in CEM-SS cells, EC50=127 nM
14698189
CHOK1 cells
Function assay
Displacement of [125I]SDF1alpha from CXCR4 expressed in CHOK1 cells, IC50=0.81 nM
17715128
GHOST CXCR4 cell line
Function assay
Inhibitory concentration of compound against HIV-1 LAI strain in GHOST CXCR4 cell line, IC50=0.95 nM
14698189
HEK293 cells
Function assay
2 days
Antiviral activity against T20-resistant HIV1 NL4-3 infected in HEK293 cells assessed as inhibition of viral replication after 2 days, IC50=2.3 nM
United States, New Jersey
... 展开 >>
University of Medicine and Dentistry of New Jersey
Recruiting
Newark, New Jersey, United States, 07101
Contact: Baburao Koneru, MD koneruba@umdnj.edu 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: Sandra Maxwell, B.S.N. 301-402-1773 maxwells@niaid.nih.gov 收起 <<
United States, New Jersey
... 展开 >>
University of Medicine and Dentistry of New Jersey
Recruiting
Newark, New Jersey, United States, 07101
Contact: Baburao Koneru, MD koneruba@umdnj.edu 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: Sandra Maxwell, B.S.N. 301-402-1773 maxwells@niaid.nih.gov 收起 <<
Accelerated Phase Chronic Myel... 展开 >>ogenous Leukemia
Adult Acute Lymphoblastic Leukemia in Remission
Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
Atypical Chronic Myeloid Leukemia, BCR-ABL Negative
Blastic Phase Chronic Myelogenous Leukemia
Chronic Phase Chronic Myelogenous Leukemia
de Novo Myelodysplastic Syndromes
Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
Nodal Marginal Zone B-cell Lymphoma
Noncontiguous Stage II Adult Burkitt Lymphoma
Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma
Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma
Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma
Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma
Noncontiguous Stage II Adult Lymphoblastic Lymphoma
Noncontiguous Stage II Grade 1 Follicular Lymphoma
Noncontiguous Stage II Grade 2 Follicular Lymphoma
Noncontiguous Stage II Grade 3 Follicular Lymphoma
Noncontiguous Stage II Mantle Cell Lymphoma
Noncontiguous Stage II Marginal Zone Lymphoma
Noncontiguous Stage II Small Lymphocytic Lymphoma
Previously Treated Myelodysplastic Syndromes
Recurrent Adult Acute Lymphoblastic Leukemia
Recurrent Adult Acute Myeloid Leukemia
Recurrent Adult Burkitt Lymphoma
Recurrent Adult Diffuse Large Cell Lymphoma
Recurrent Adult Diffuse Mixed Cell Lymphoma
Recurrent Adult Diffuse Small Cleaved Cell Lymphoma
Recurrent Adult Hodgkin Lymphoma
Recurrent Adult Immunoblastic Large Cell Lymphoma
Recurrent Adult Lymphoblastic Lymphoma
Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma
Recurrent Grade 1 Follicular Lymphoma
Recurrent Grade 2 Follicular Lymphoma
Recurrent Grade 3 Follicular Lymphoma
Recurrent Mantle Cell Lymphoma
Recurrent Marginal Zone Lymphoma
Recurrent Mycosis Fungoides/Sezary Syndrome
Recurrent Small Lymphocytic Lymphoma
Refractory Chronic Lymphocytic Leukemia
Refractory Hairy Cell Leukemia
Refractory Multiple Myeloma
Relapsing Chronic Myelogenous Leukemia
Secondary Acute Myeloid Leukemia
Secondary Myelodysplastic Syndromes
Splenic Marginal Zone Lymphoma
Stage I Multiple Myeloma
Stage II Multiple Myeloma
Stage III Adult Burkitt Lymphoma
Stage III Adult Diffuse Large Cell Lymphoma
Stage III Adult Diffuse Mixed Cell Lymphoma
Stage III Adult Diffuse Small Cleaved Cell Lymphoma
Stage III Adult Hodgkin Lymphoma
Stage III Adult Immunoblastic Large Cell Lymphoma
Stage III Adult Lymphoblastic Lymphoma
Stage III Chronic Lymphocytic Leukemia
Stage III Grade 1 Follicular Lymphoma
Stage III Grade 2 Follicular Lymphoma
Stage III Grade 3 Follicular Lymphoma
Stage III Mantle Cell Lymphoma
Stage III Marginal Zone Lymphoma
Stage III Multiple Myeloma
Stage III Small Lymphocytic Lymphoma
Stage IV Adult Burkitt Lymphoma
Stage IV Adult Diffuse Large Cell Lymphoma
Stage IV Adult Diffuse Mixed Cell Lymphoma
Stage IV Adult Diffuse Small Cleaved Cell Lymphoma
Stage IV Adult Hodgkin Lymphoma
Stage IV Adult Immunoblastic Large Cell Lymphoma
Stage IV Adult Lymphoblastic Lymphoma
Stage IV Chronic Lymphocytic Leukemia
Stage IV Grade 1 Follicular Lymphoma
Stage IV Grade 2 Follicular Lymphoma
Stage IV Grade 3 Follicular Lymphoma
Stage IV Mantle Cell Lymphoma
Stage IV Marginal Zone Lymphoma
Stage IV Small Lymphocytic Lymphoma 收起 <<
Not Applicable
Terminated(Funding withdrawal)
-
United States, Washington
... 展开 >>
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Seattle, Washington, United States, 98109 收起 <<
United Kingdom
... 展开 >> Dept of Haematology, University of Liverpool
Recruiting
Liverpool, Merseyside, United Kingdom, L7 8XP
Principal Investigator: Richard E Clark, BA, MB, BS 收起 <<
United States, Massachusetts
... 展开 >>
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Cape Cod Hospital
Hyannis, Massachusetts, United States, 02601
Milford Hospital
Milford, Massachusetts, United States, 01757
Newton-Wellesley Hospital
Newton, Massachusetts, United States, 02462
United States, Pennsylvania
Cancer Treatment Centers of America (Eastern Regional Medical Center)
Philadelphia, Pennsylvania, United States, 19124 收起 <<
China
... 展开 >> Investigational Site Number 156017
Beijing, China, 100034
Investigational Site Number 156001
Beijing, China, 100044
Investigational Site Number 156005
Beijing, China, 100071
Investigational Site Number 156002
Beijing, China, 100142
Investigational Site Number 156003
Beijing, China, 100730
Investigational Site Number 156020
Chongqing, China, 400037
Investigational Site Number 156016
Fuzhou, China, 350001
Investigational Site Number 156021
Guangzhou, China, 510060
Investigational Site Number 156011
Hangzhou, China, 310003
Investigational Site Number 156018
Nanjing, China, 210029
Investigational Site Number 156009
Shanghai, China, 200025
Investigational Site Number 156010
Suzhou, China, 215006
Investigational Site Number 156008
Tianjin, China, 300020
Investigational Site Number 156013
Wuhan, China, 430022
Investigational Site Number 156015
Xi'An, China, 710038
Investigational Site Number 156022
Zhengzhou, China, 450008 收起 <<
United States, Ohio
... 展开 >>
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195 收起 <<
United Kingdom
... 展开 >> Aberdeen Royal Infirmary
Aberdeen, United Kingdom
Belfast City Hospital
Belfast, United Kingdom
Birmingham Heartlands Hospital
Birmingham, United Kingdom
Addenbrooke's Hospital
Cambridge, United Kingdom
University Hospital of Wales
Cardiff, United Kingdom
Castle Hill Hospital
Hull, United Kingdom
St James's University Hospital
Leeds, United Kingdom
Royal Liverpool University Hospital
Liverpool, United Kingdom
St Bartholomew's Hospital
London, United Kingdom
Christie Hospital
Manchester, United Kingdom
Manchester Royal Infirmary
Manchester, United Kingdom
Freeman Hospital
Newcastle, United Kingdom
Nottingham University Hospital
Nottingham, United Kingdom 收起 <<
United States, California
... 展开 >>
City of Hope National Medical Center
Duarte, California, United States, 91010
United States, Colorado
University of Colorado Cancer Center
Aurora, Colorado, United States, 80045
Canada, Ontario
Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
St. Mary's Hospital
Seoul, Korea, Republic of, 137-701
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 10002
Taipei Veterans General Hospital
Taipei, Taiwan, 10002 收起 <<
Terminated(Insufficient cell m... 展开 >>obilization for tandem transplants) 收起 <<
-
United States, New York
... 展开 >>
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
United States, Pennsylvania
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107 收起 <<
United States, Massachusetts
... 展开 >>
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Massachusetts General Hospital
Boston, Massachusetts, United States, 02214 收起 <<
United States, Missouri
... 展开 >>
Washington University School of Medicine,Division of Bone Marrow Transplantation & Leukemia
St Louis, Missouri, United States, 63110-1093 收起 <<
Russian Federation
... 展开 >>
Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and Immunology
Recruiting
Moscow, Russian Federation, 117997
Contact: Dmitry Balashov, MD, PhD +7(495)287-6570 ext 6534 bala8@yandex.ru
Contact: Michael Maschan, Professor +7(926)287-6570 mmaschan@yandex.ru
Sub-Investigator: Michael Maschan, Professor
Sub-Investigator: Alexandra Laberko, MD
Sub-Investigator: Svetlana Kozlovskaya, MD
Sub-Investigator: Elena Gutovskaya, MD
Sub-Investigator: Anna Shcherbina, Professor 收起 <<
Canada, Alberta
... 展开 >>
Tom Baker Cancer Center
Calgary, Alberta, Canada, T2N 4N2
Canada, British Columbia
Vancouver General Hospital, BC Cancer Agency
Vancouver, British Columbia, Canada, V5Z 4E3 收起 <<
Belgium
... 展开 >> Investigational Site Number 056002
Brugge, Belgium, B-8000
Estonia
Investigational Site Number 233001
Tallinn, Estonia, 13419
Lithuania
Investigational Site Number 440001
Vilnius, Lithuania, LT-08661
Sweden
Investigational Site Number 752001
Stockholm, Sweden, 14186
Investigational Site Number 752002
Umeå, Sweden, 901 85 收起 <<
Multiple Myeloma
... 展开 >> Refractory Multiple Myeloma
Stage I Multiple Myeloma
Stage II Multiple Myeloma
Stage III Multiple Myeloma 收起 <<
Phase 2
Completed
-
United States, Arizona
... 展开 >>
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905 收起 <<
Germany
... 展开 >> University of Cologne
Cologne, Germany
Carl Gustav Carus University Hospital
Dresden, Germany
University of Heidelberg
Heidelberg, Germany 收起 <<
Japan
... 展开 >> Investigational Site Number 392005
Chiba-Shi, Japan
Investigational Site Number 392011
Fukuoka-Shi, Japan
Investigational Site Number 392014
Fukuyama-Shi, Japan
Investigational Site Number 392010
Hamamatsu-Shi, Japan
Investigational Site Number 392006
Kamogawa-Shi, Japan
Investigational Site Number 392003
Kobe-Shi, Japan
Investigational Site Number 392008
Kurashiki-Shi, Japan
Investigational Site Number 392015
Ota-Shi, Japan
Investigational Site Number 392004
Sapporo-Shi, Japan
Investigational Site Number 392001
Shibuya-Ku, Japan
Investigational Site Number 392009
Suwa-Shi, Japan
Investigational Site Number 392007
Toyohashi-Shi, Japan 收起 <<
United States, Arkansas
... 展开 >>
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
United States, California
UCLA School of Medicine
Loa Angeles, California, United States
United States, Illinois
Loyola University Medical Center
Maywood, Illinois, United States
United States, Iowa
University of Iowa
Iowa City, Iowa, United States
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
United States, New York
Roswell Park Cancer Institute
Buffalo, New York, United States
United States, Pennsylvania
Thomas Jefferson University
Philadelphia, Pennsylvania, United States 收起 <<
Japan
... 展开 >> Investigational Site Number 392105
Kamogawa-Shi, Japan
Investigational Site Number 392103
Kyoto-Shi, Japan
Investigational Site Number 392102
Nagoya-Shi, Japan
Investigational Site Number 392104
Okayama-Shi, Japan
Investigational Site Number 392101
Shibuya-Ku, Japan 收起 <<
United States, California
... 展开 >>
City of Hope National Medical Center
Duarte, California, United States
United States, Indiana
Indiana Blood and Marrow Transplantation
Beech Grove, Indiana, United States
United States, New York
University of Rochester Medical Center
Rochester, New York, United States
United States, Oregon
Oregon Health and Science University
Portland, Oregon, United States
United States, Washington
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States 收起 <<
United States, California
... 展开 >>
City of Hope National Medical Center`
Duarte, California, United States, 91010
United States, Florida
H. Lee Moffitt Cancer Center
Tampa, Florida, United States, 33612-9497
United States, Georgia
Blood & Marrow Transplant Group of Georgia
Atlanta, Georgia, United States, 30342
United States, Mississippi
University of Mississippi Medical Center, Div of Hematology
Jackson, Mississippi, United States, 39216
United States, Missouri
Kansas City Cancer Centers
Kansas City, Missouri, United States, 64111
United States, New Jersey
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
United States, Virginia
Virginia Commonwealth University - Massey Cancer Center
Richmond, Virginia, United States, 23298-0037
United States, Wisconsin
University of Wisconsin, Blood and Bone Marrow Transplant
Madison, Wisconsin, United States, 53792-5156 收起 <<
United States, California
... 展开 >>
UCLA Medical Center
Los Angeles, California, United States, 90095
United States, Georgia
Emory University-Winship Cancer Institute
Atlanta, Georgia, United States, 30322
United States, Indiana
Indiana Blood and Marrow Transplant
Indianapolis, Indiana, United States, 46237
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, North Carolina
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157
United States, Ohio
Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Columbus, Ohio, United States, 43210
United States, Virginia
University of Virginia Medical Center
Charlottesville, Virginia, United States, 22908
Virginia Commonwealth University Medical Center
Richmond, Virginia, United States, 23298 收起 <<
Lymphoma (Non-Hodgkin's Lympho... 展开 >>ma)
Hodgkin's Disease or Multiple Myeloma
Front Line Mobilization
Transplantation 收起 <<
Phase 3
Completed
-
France
... 展开 >> Hôpital du Haut Lévêque
Bordeaux, France
Hôpital Lyon Sud
Lyon, France
Institut Paoli Calmettes
Marseille, France
CHU Hotel-Dieu Université de Nantes
Nantes, France
Hôpital Saint-Louis
Paris, France
Institut Gustave Roussy
Villejuif, France
Germany
Charité - Campus Benjamin Franklin
Berlin, Germany
Klinikum der Universität zu Köln
Cologne, Germany
Universitätsklinikum Carl Gustav Carus
Dresden, Germany
Universitätsklinikum Heidelberg
Heidelberg, Germany
Klinikum Nürnberg Nord
Nürnberg, Germany
Universitätsklinik Würzburg
Würzburg, Germany
Italy
L. & A. Seragnoli, University of Bologna
Bologna, Italy
Ospedale Ferrarotto
Catania, Italy
Azienda Ospedaliera S. Martino
Genova, Italy
Netherlands
VU Medisch Centrum
Amsterdam, Netherlands
Spain
Hospital Santa Creu y Sant Pau
Barcelona, Spain
Hospital Carlos-Haya
Malaga, Spain
Hospital Universitario de Salamanca
Salamanca, Spain
Hospital la Fe
Valencia, Spain
Sweden
Karolinska Universitetssjukhuset Huddinge
Stockholm, Sweden
Akademiska Sjukhuset
Uppsala, Sweden
United Kingdom
Gartnavel Hospital
Glasgow, United Kingdom
St James's University Hospital
Leeds, United Kingdom
King's college Hospital
London, United Kingdom
Nottingham University NHS Trust
Nottingham, United Kingdom 收起 <<
United States, Ohio
... 展开 >>
The Christ Hospital
Recruiting
Cincinnati, Ohio, United States, 45219
Contact: E. Steve Woodle, MD 513-558-6001 Woodlees@uc.edu
Sub-Investigator: Adele Rike-Shields, PharmD
Sub-Investigator: Michael Cardi, MD
Principal Investigator: Ervin S Woodle, MD
University of Cincinnati
Recruiting
Cincinnati, Ohio, United States, 45267
Contact: E. Steve Woodle, MD 513-558-6001 Woodlees@uc.edu
Sub-Investigator: Rita R Alloway, PharmD
Principal Investigator: Ervin S Woodle, MD
Sub-Investigator: Amit Govil, MD 收起 <<
United States, California
... 展开 >>
Duarte, California, United States
United States, Massachusetts
Boston, Massachusetts, United States
United States, Michigan
Ann Arbor, Michigan, United States
United States, Missouri
St. Louis, Missouri, United States
United States, New York
Rochester, New York, United States
United States, Ohio
Cleveland, Ohio, United States
United States, Texas
Houston, Texas, United States
United States, Washington
Seattle, Washington, United States 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov
United States, Tennessee
St. Jude Childrens Research Hospital
Recruiting
Memphis, Tennessee, United States, 38105
Contact: Akshay Sharma Not Listed Akshay.Sharma@stjude.org 收起 <<
United States, California
... 展开 >>
Apex Research of Riverside
Santa Ana, California, United States, 92705
United States, Minnesota
Prism Research, 1000 Westgate Dr. suite 149
St. Paul, Minnesota, United States, 55114
United States, Nebraska
Creighton University Medical Center
Omaha, Nebraska, United States, 68131 收起 <<
United States, California
... 展开 >>
UCSD Moores Cancer Center
La Jolla, California, United States
United States, Ohio
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
United States, Texas
UTMD Anderson Cancer Center
Houston, Texas, United States 收起 <<
United States, California
... 展开 >>
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto, California, United States, 94304
Contact: Lawrence Recht 650-725-8630 lrecht@stanford.edu
Principal Investigator: Lawrence Recht 收起 <<
United States, New York
... 展开 >>
Memorial Sloan Kettering Cancer Center
Recruiting
New York, New York, United States, 10065
Contact: Farid Boulad, MD 212-639-6684
Contact: Susan Prockop, MD 212-639-6715
Principal Investigator: Farid Boulad, MD
Weill Cornell Medical College
Recruiting
New York, New York, United States, 10065
Contact: Tsiporah Shore, MD 212-746-2646 收起 <<
United States, New York
... 展开 >>
Weill Cornell Medical College
New York, New York, United States, 10065
United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom, CB2 0QQ 收起 <<
Mexico
... 展开 >> Servicio de Hematología Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo Leon
Recruiting
Monterrey, Nuevo Leon, Mexico, 64460
Contact: Perla Colunga Pedraza, MD +528110761973 colunga.perla@gmail.com
Contact: Guillermo Sotomayor Duque, MD 收起 <<
United States, North Carolina
... 展开 >>
Duke University Medical Center
Durham, North Carolina, United States, 27705
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425 收起 <<
United States, New York
... 展开 >>
Mount Sinai School of Medicine
Recruiting
New York, New York, United States, 10029
Contact: Patricia A Shi, MD 212-241-9237 patricia.shi@mssm.edu
Contact: Luis M Isola, MD 212-241-6021 luis.isola@msnyuhealth.org
Principal Investigator: Patricia A Shi, MD
Sub-Investigator: Luis M Isola, MD 收起 <<
Related Donors Donating PBSC t... 展开 >>o a Family Member
Acute Myelogenous Leukemia
Acute Lymphoblastic Leukemia
Myelodysplastic Syndrome
Chronic Myelogenous Leukemia
Non-Hodgkin's Lymphoma
Hodgkin's Disease
Chronic Lymphocytic Leukemia 收起 <<
Phase 2
Completed
-
United States, Florida
... 展开 >>
H. Lee Moffitt Cancer Center
Tampa, Florida, United States
United States, Georgia
Emory University
Atlanta, Georgia, United States
United States, Illinois
University of Chicago
Chicago, Illinois, United States
United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
United States, Missouri
Washington University
Saint Louis, Missouri, United States
United States, North Carolina
Duke University
Durham, North Carolina, United States
United States, Ohio
Cleveland Clinic
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
United States, West Virginia
West Virginia University
Morgantown, West Virginia, United States
United States, Wisconsin
Medical College of Wisconsin
Milwaukee, Wisconsin, United States 收起 <<
United Kingdom
... 展开 >> Addenbrookes Hospital
Recruiting
Cambridge, United Kingdom, CB2 0QQ
Contact: Lisa Bax lisa.bax@addenbrookes.nhs.uk
Principal Investigator: Bristi Basu, Dr 收起 <<
United States, California
... 展开 >>
City of Hope Medical Center
Recruiting
Duarte, California, United States, 91010
Contact: Joseph Rosenthal, MD 626-256-4673 ext 88442 jrosenthal@coh.org
Principal Investigator: Joseph Rosenthal, MD 收起 <<
Relapsed/Refractory AML
... 展开 >> Relapsed/Refractory ALL
Secondary AML/MDS
Acute Leukemia of Ambiguous Lineage
AML
ALL 收起 <<
Phase 1
Completed
-
United States, Arizona
... 展开 >>
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
United States, Colorado
The Children's Hospital of Denver
Denver, Colorado, United States, 80045
United States, Georgia
Children's Healthcare of Atlanta/Emory University
Atlanta, Georgia, United States, 30322
United States, Maryland
Johns Hopkins Medical Center
Baltimore, Maryland, United States, 21231
United States, Missouri
The Children's Mercy Hospital and Clinics
Kansas City, Missouri, United States, 64108
United States, New York
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
United States, Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
United States, Pennsylvania
Penn State Hershey Children's Hospital
Hershey, Pennsylvania, United States, 17033
Canada, Alberta
Alberta Children's Hospital
Calgary, Alberta, Canada, T3B 6A8 收起 <<
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