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Amsilarotene {[allProObj[0].p_purity_real_show]}

货号:A603641 同义名: TAC-101;Am 555S

Amsilarotene (TAC-101; Am 555S) 是一种口服活性的合成类视黄醇,对视黄酸受体 α (RAR-α) 具有选择性亲和力,诱导多种癌细胞凋亡,可用于癌症研究。

Amsilarotene 化学结构 CAS号:125973-56-0
Amsilarotene 化学结构
CAS号:125973-56-0
Amsilarotene 3D分子结构
CAS号:125973-56-0
Amsilarotene 化学结构 CAS号:125973-56-0
Amsilarotene 3D分子结构 CAS号:125973-56-0
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Amsilarotene 纯度/质量文件 产品仅供科研

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Amsilarotene 生物活性

描述 Amsilarotene (TAC-101; Am 555S), a synthetic orally active retinoid, selectively binds to retinoic acid receptor α (RAR-α) with dissociation constants of 2.4 and 400 nM for RAR-α and RAR-β, respectively. It promotes apoptosis in cells of human gastric cancer, hepatocellular carcinoma, and ovarian carcinoma, and is useful for cancer research[1][2][3].
体内研究

Administered orally at 8 mg/kg/day for 30 days, Amsilarotene inhibits RMG-II tumor growth in nude mice[2].

体外研究

Amsilarotene (0, 10, 25 μM; 24 hours) triggers apoptosis in human epithelial ovarian carcinoma-derived cell lines dose-dependently[2].

Amsilarotene (10, 20 μM; over 0, 3, 6, and 9 days) suppresses the growth of BxPC-3 and MIAPaCa-2 cells[3].

Amsilarotene (10 μM; 48 hours) increases the proportion of BxPC-3 cells in the G1 phase[3].

Amsilarotene (10 μM; 0, 3, 6, 24, 48, 72 hours) blocks phosphorylation of the retinoblastoma gene product (RB) in BxPC-3 cells from 24 to 72 hours[3].

Amsilarotene 参考文献

[1]Sun SY, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997 Nov 1;57(21):4931-9.

[2]Suzuki N, et al. A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma. Gynecol Oncol. 2004 Sep;94(3):

[3]Fujimoto K, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999 May 17;81(4):637-44.

Amsilarotene 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.97mL

2.59mL

1.30mL

25.93mL

5.19mL

2.59mL

Amsilarotene 技术信息

CAS号125973-56-0
分子式C20H27NO3Si2
分子量 385.604
别名 TAC-101;Am 555S
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(272.3 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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