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Amentoflavone

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Chemical Structure| 1617-53-4 同义名 : Didemethyl-ginkgetin;NSC 295677;38Biapigenin
CAS号 : 1617-53-4
货号 : A421989
分子式 : C30H18O10
纯度 : 98%
分子量 : 538.458
MDL号 : MFCD00017470
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(222.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Amentoflavone is the main component of Selaginella tamariscina widely known as an oriental traditional medicinal stuff that has been known to have a variety of medicinal effects such as the induction of apoptosis, antimetastasis, and anti-inflammation. Amentoflavone could play a positive role in the inhibition of various diseases associated with autophagy and the modulation of p53[3]. Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting the NLRP3 inflammasome and, thus, mediating the inflammatory process in PTZ(pentylenetetrazole)-induced kindling mice and LPS(lipopolysaccharide)-induced BV2 microglial cells[4]. In vivo, the tumor growth was suppressed by AF (Amentoflavone) in a dose-dependent manner. The level of MDA (malondialdehyde) in the tumor tissue was increased while the level of GSH (reduced glutathione) in tumor tissue was decreased by AF in a dose-dependent manner. Furthermore, the expression of LC3B, Beclin1, ATG5, ATG7 were increased, and the expression of FTH (ferritin heavy chain) were decreased by AF in a dose-dependent manner in vivo[5]. Amentoflavone inhibits HCC (hepatocellular carcinoma) progression through suppression of ERK(extracellular signal-regulated kinase )/NF-ĸB (nuclear factor-kappaB) signaling[6]. In addition, amentoflavone improves the osteogenesis of hMSCs (human mesenchymal stem cells) through the JNK and p38 MAPK pathway[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.29mL

1.86mL

0.93mL

18.57mL

3.71mL

1.86mL
参考文献

[1]Lv X, Zhang JB, et al. Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases. Chem Biol Interact. 2018.

[2]Sakthivel KM, Guruvayoorappan C. Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-κB signal transduction pathways in rats with ulcerative colitis. Int Immunopharmacol. 2013 Nov;17(3):907-16.

[3]Park HJ, Kim MM. Amentoflavone Induces Autophagy and Modulates p53. Cell J. 2019 Apr;21(1):27-34

[4]Rong S, Wan D, Fan Y, Liu S, Sun K, Huo J, Zhang P, Li X, Xie X, Wang F, Sun T. Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome. Front Pharmacol. 2019 Jul 30;10:856

[5]Chen Y, Li N, Wang H, Wang N, Peng H, Wang J, Li Y, Liu M, Li H, Zhang Y, Wang Z. Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. Life Sci. 2020 Apr 15;247:117425

[6]Lee KC, Chen WT, Liu YC, Lin SS, Hsu FT. Amentoflavone Inhibits Hepatocellular Carcinoma Progression Through Blockage of ERK/NF-ĸB Activation. In Vivo. 2018 Sep-Oct;32(5):1097-1103

[7]Zha X, Xu Z, Liu Y, Xu L, Huang H, Zhang J, Cui L, Zhou C, Xu D. Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways. J Nat Med. 2016 Jul;70(3):634-44